|
Hypertensive disease
|
0.370 |
GeneticVariation
|
group |
BEFREE |
P-selectin gene polymorphism associates with pulmonary hypertension in congenital heart disease.
|
26261613 |
2015 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
|
19395438 |
2009 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart disease (CHD) and ischemic stroke among 13,875 participants in the prospective Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we examined the association of the P-selectin Thr715Pro polymorphism with incident coronary heart disease (CHD) and ischemic stroke among 14595 participants in the prospective cohort of the Atherosclerosis Risk in Communities (ARIC) Study.
|
16125711 |
2006 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
The effect of SELE and SELP genetic polymorphisms on the pathogenesis of MI was investigated in this meta-analysis with a total of ten case-control studies, including 2,696 MI patients and 4,724 healthy subjects.
|
24639176 |
2014 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
However, we observed no significant associations between SELP genetic polymorphisms and the risk of CHD and MI among Africans.
|
24504449 |
2014 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
Specific haplotypes of the P-selectin gene are associated with myocardial infarction.
|
12165563 |
2002 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
The ECTIM (étude cas-temoin de l'infarctus myocarde) extension study was established to determine whether a previously implicated polymorphism of the P-selectin gene was associated with myocardial infarction risk in men and women in Belfast and Glasgow.
|
11040019 |
2000 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
LHGDN |
Specific haplotypes of the P-selectin gene are associated with myocardial infarction.
|
12165563 |
2002 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, rs1131498" genes_norm="6402">F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286).
|
26662939 |
2016 |
|
Myocardial Infarction
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
We illustrate the method with three applications on the relationship between (1). the P-selectin gene and myocardial infarction, (2). the cholesteryl ester transfer protein gene and plasma high-density-lipoprotein cholesterol concentration, and (3). genes of the renin-angiotensin-aldosterone system and myocardial infarction.
|
12902385 |
2003 |
|
Diabetic Nephropathy
|
0.220 |
GeneticVariation
|
disease |
BEFREE |
Genes associated with DN, T2D, and vascular diseases do not appear to be consistently associated with DR. A few genetic variants associated with DR, particularly those in SELP and near IDUA, should be investigated in additional DR cohorts.
|
21873659 |
2011 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
|
19395438 |
2009 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we examined the association of the P-selectin Thr715Pro polymorphism with incident coronary heart disease (CHD) and ischemic stroke among 14595 participants in the prospective cohort of the Atherosclerosis Risk in Communities (ARIC) Study.
|
16125711 |
2006 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart disease (CHD) and ischemic stroke among 13,875 participants in the prospective Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Studied SELP -2028 C/T seems to be a novel attractive predictive factor of cancer malnutrition in HNC patients, perhaps in a future, patients carrying unfavorable CC genotype could be earlier scheduled for pharmaceutical intervention with parenterall nutrition, therefore they could be prevented from the development of severe malnutrition or even cachexia.
|
30617759 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease.
|
12911583 |
2003 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Age modification of ozone associations with cardiovascular disease risk in adults: a potential role for soluble P-selectin and blood pressure.
|
30174917 |
2018 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results support an important association of rs1800805, rs6136 minor allele of SELP gene, rs1800796 within IL-6 gene, and additional interaction between rs1800805 and rs1800796 with increased risk of CVD.
|
28819827 |
2017 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Contrary to expectations, the present analyses showed that older patients with cardiovascular disease with the SELP 1087A allele performed more poorly on neuropsychological testing.
|
19590054 |
2009 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Several studies have attempted to demonstrate the association of the most intensively examined variant of P-selectin gene polymorphism (Thr715Pro) with sP-selectin levels in healthy subjects and in CVD, but contradictory data have been reported.
|
17598012 |
2007 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this was the first case-control study to be performed on an Arab/North-African population, and demonstrates that none of the five P-selectin polymorphisms investigated influence CHD susceptibility in Tunisian Arabs.
|
19082691 |
2009 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analyses showed the PSEL NNVP haplotype to be a significant predictor of incident CHD in whites (HRR 2.09, 95%CI 1.23-3.55, P=0.006).
|
17420019 |
2007 |