|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
RGD |
Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia-reperfusion injury in an in vivo rat model.
|
21146547 |
2011 |
|
Myocardial Reperfusion Injury
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
|
12087064 |
2002 |
|
Hypertensive disease
|
0.370 |
AlteredExpression
|
group |
BEFREE |
CR in ischemic stroke patients is associated with several independent predictors, including increased platelet activation marker CD62p, decreased vitamin D level, and hypertension.
|
30795966 |
2019 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
All 3 viral miRNAs associated with combinations of inflammatory or prothrombotic circulating biomarkers (sTNFRII, IL-6, sICAM1, OPG, P-selectin) but did not associate with hypertension, coronary heart disease or cancer.
|
29686252 |
2018 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
Impacts of serum P-selectin on blood pressure control after PCI in patients with coronary heart disease complicated with hypertension.
|
28745786 |
2017 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
CD62P+MP counts were higher in MI patients with diabetes (p=0.020), and patients with hypertension had increased levels of CD14+MPs (p=0.004).
|
28424820 |
2017 |
|
Hypertensive disease
|
0.370 |
GeneticVariation
|
group |
BEFREE |
P-selectin gene polymorphism associates with pulmonary hypertension in congenital heart disease.
|
26261613 |
2015 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
BEFREE |
To evaluate the possible influence of family history of hypertension on some indicators of early atherosclerosis, we studied eighty-five healthy normotensive individuals with (FH+) or without (FH-) family history of essential hypertension by measuring metabolic profile and concentrations of P-selectin, interleukin 6 and matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1.
|
19339995 |
2009 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
LHGDN |
We investigated the association of extreme blood pressure (BP) elevation with platelet P-selectin and fibrinolytic markers in high risk patients with severe hypertension.
|
16764881 |
2007 |
|
Hypertensive disease
|
0.370 |
Biomarker
|
group |
CTD_human |
Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine-based antihypertensive therapy.
|
15513305 |
2004 |
|
Thrombosis
|
0.320 |
Biomarker
|
phenotype |
LHGDN |
Thrombin-mediated endothelial-cell release of von Willebrand factor (VWF) and P-selectin functionally links protease-activated receptors (PARs) to thrombosis and inflammation.
|
16332977 |
2006 |
|
Thrombosis
|
0.320 |
Biomarker
|
phenotype |
LHGDN |
Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers.
|
16648968 |
2006 |
|
Thrombosis
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
A flow cytometric assay of platelet activation marker P-selectin (CD62P) distinguishes heparin-induced thrombocytopenia (HIT) from HIT with thrombosis (HITT).
|
10544909 |
1999 |
|
Myocardial Ischemia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Myocardial Ischemia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We present evidence that genetic disruption of PARS provides protection against myocardial ischemia and reperfusion injury by inhibiting the expression of P-selectin and intercellular adhesion molecule-1 (ICAM-1) and, consequently, by inhibiting the recruitment of neutrophils into the jeopardized tissue.
|
9670921 |
1998 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Factors promoting thrombosis such as von Willebrand factor (vWF) and P-selectin are essential for the development of atherosclerosis (AS) and arterial thrombosis.
|
31450612 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Herein, we investigated the role of P-selectin and its receptor P-selectin glycoprotein ligand (PSGL)-1 on atherosclerosis via activation of DCs.
|
31263109 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our objective was to determine whether the circulating adhesion molecules soluble intracellular adhesion molecule (sICAM)-1, soluble vascular cell adhesion molecule (sVCAM)-1 and P-selectin are associated with subclinical ILD in community-dwelling adults.The Multi-Ethnic Study of Atherosclerosis enrolled males and females aged 45-84 years from six communities in the United States in 2000-2002.
|
31371443 |
2019 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Compound 6b also inhibited platelet P-selectin expression and thus may diminish atherosclerosis.
|
27996269 |
2017 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Patients with atherosclerosis in three arterial beds, i. e. coronary, carotid and peripheral arteries, had lower concentrations of CD62P+TF+MPs (p=0.035) and CD144+TF+MPs (p=0.004) compared to patients with atherosclerosis in one or two arterial beds.
|
28424820 |
2017 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Atherosclerosis-prone mice crossed with P-selectin-deficient (Selp(-/-)) mice develop smaller lesions.
|
27102967 |
2016 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
To confirm this hypothesis, a P‑selectin inhibitor was administered to an atherosclerosis formation model, plaque rapture model and neointimal hyperplasia model.
|
25384966 |
2015 |
|
Endogenous depression
|
0.300 |
Biomarker
|
disease |
CTD_human |
Platelet hyperactivity, neurobehavioral symptoms and depression among Indian women chronically exposed to low level of arsenic.
|
25451969 |
2014 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Platelet hyperactivity, neurobehavioral symptoms and depression among Indian women chronically exposed to low level of arsenic.
|
25451969 |
2014 |
|
Melancholia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Platelet hyperactivity, neurobehavioral symptoms and depression among Indian women chronically exposed to low level of arsenic.
|
25451969 |
2014 |