SELP, selectin P, 6403

N. diseases: 293; N. variants: 23
Disease: Anemia, Sickle Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE We anticipate that blockade of TLR4, P-selectin, or the complement system could prevent liver injury in hemolytic diseases like sickle cell disease. 30850533 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE The cell adhesion molecule P-selectin plays a key role in the pathogenesis of a vaso-occlusive crisis (VOC) in patients with sickle cell disease (SCD). 30295335 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 AlteredExpression disease BEFREE We examined the mechanism of mast cell-induced endothelial activation <i>via</i> endoplasmic reticulum (ER) stress mediated P-selectin expression in a transgenic mouse model of sickle cell disease (SCD), which shows BBB dysfunction. 30837844 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 AlteredExpression disease BEFREE Vascular function in SCD::Keap1F/F::Tie1-Cre mice was significantly improved, with a 50% decrease in vascular leakage and low expression of the adhesion molecules Vcam1 and P-selectin. 31015205 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE Inhibition of platelet P-selectin with function-blocking antibody attenuated the neutrophil-platelet interactions in SCD patient blood in vitro and resolved pulmonary arteriole microembolism in SCD mice in vivo. 28097236 2017
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE High levels of both soluble E-selectin (sE-selectin) and soluble P-selectin (sP-selectin) markers were demonstrated in the serum of patients with SCD during both steady state and acute VOC. 27686084 2017
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE The safety and efficacy of crizanlizumab, an antibody against the adhesion molecule P-selectin, were evaluated in patients with sickle cell disease. 27959701 2017
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE The pretreatment of mice with SCD with clopidogrel or P-selectin antibody reduced the formation of PNAs and neutrophil activation and decreased lung vascular permeability. 21071696 2010
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype. 18080800 2008
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 Biomarker disease BEFREE Platelet P-selectin and platelet mass, volume and component in sickle cell disease: relationship to genotype. 16051315 2006
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.100 AlteredExpression disease BEFREE Sickle cell disease promotes an increased P-selectin expression in several vascular beds. 15280076 2004