SELP, selectin P, 6403

N. diseases: 293; N. variants: 23
Disease: Endotoxemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.030 AlteredExpression phenotype BEFREE PAR-1 inhibition did not affect thrombomodulin, soluble P-selectin and platelet factor-4 concentrations.PAR-1 inhibition significantly reduced the activation of coagulation, fibrinolysis, the inflammatory response and endothelial activation during experimental human endotoxemia. 29864779 2018
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.030 Biomarker phenotype BEFREE Decreased CD162 expression associated with endotoxemia reduced the binding of PLT to monocytes through membrane CD162-CD62P, favoring the inflammatory response of onset flare UC patients. 29529212 2018
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.030 Biomarker phenotype BEFREE Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. 20498830 2010