|
Acute appendicitis NOS (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the laparoscopic group, 19 (23.75%) patients had complicated acute appendicitis (CLA group), and 61 (76.25%) had uncomplicated acute appendicitis (UCLA group).
|
28708770 |
2017 |
|
Acute Chest Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Circulating peripheral CD14++CD16+ monocytes expressed PSGL-1 more frequently than CD14++CD16- and CD14+CD16+ monocytes in patients with ACS.
|
24583418 |
2014 |
|
Acute Chest Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
PSGL-1 contributed to cytotoxic CD4 T cell homing to the culprit coronary artery and promoted plaque instability in ACS.
|
29962384 |
2018 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
We investigated whether P-selectin glycoprotein ligand-1 (PSGL-1)-expressing CD4 T cells contribute to plaque instability in acute coronary syndrome (ACS).Methods and Results:We studied the adhesion molecules on CD4 T cells from consecutive patients with ACS treated with thrombus-aspirating device and compared them with healthy controls (n=48 each).
|
29962384 |
2018 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography.
|
24583418 |
2014 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43.
|
31461905 |
2019 |
|
Acute respiratory distress
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genome-Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor.
|
29425463 |
2018 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Close collaboration between the ophthalmologist and the internist will facilitate a more precise diagnosis of ocular involvement in amyloidosis and allow the multidisciplinary management of these patients.<b>Abbreviations:</b> CD: corneal dystrophy; CLA: corneal lattice amyloidosis; CNS: central nervous system; CT: computed tomography; FAP: familial amyloidotic polyneuropathy; GDLCD: gelatinous drop-like corneal dystrophy; GLN: gelsolin; LCD: lattice corneal dystrophy; MRI: magnetic resonance imaging; OLT: orthotopic liver transplantation; TEM: transmission electron microscopy; TGFBI: transforming growth factor β induced; TTR: transthyretin.
|
31829761 |
2020 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Amyotrophic Lateral Sclerosis, Familial
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Anthrax disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Soluble P-selectin rescues mice from anthrax lethal toxin-induced mortality through PSGL-1 pathway-mediated correction of hemostasis.
|
28102766 |
2017 |
|
Antiphospholipid Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
P-selectin glycoprotein ligand-1 (PSGL-1) variable number of tandem repeat (VNTR) polymorphism has an impact on the protein length, and heterozygosity affect of the PSGL-1 to P-selectin interaction, which has been found to be associated with an increased risk of thrombosis in patients with antiphospholipid syndrome.
|
28809090 |
2018 |
|
Antiphospholipid Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We compared the PSGL-1 VNTR allele and genotype frequencies in 90 patients with antiphospholipid syndrome (APS) with thrombosis, 39 patients with persistent aPLA positivity without thrombosis, and 203 healthy controls.
|
17545190 |
2007 |
|
Aplastic Anemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The adhesive molecules of bone marrow mesenchymal stem cells (BMMSCs) in AA model, VLA-4, VCAM-1, and ICAM-1 were upregulated, and those of CD162 and CD164 were downregulated by CIHH pretreatment.
|
28798776 |
2017 |
|
Appendicitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the laparoscopic group, 19 (23.75%) patients had complicated acute appendicitis (CLA group), and 61 (76.25%) had uncomplicated acute appendicitis (UCLA group).
|
28708770 |
2017 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
P-selectin and P-selectin glycoprotein ligand (SELPLG, selectin P ligand) constitute a receptor/ligand complex that is likely to be involved in the development of atherosclerosis and its complications.
|
14641238 |
2003 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
|
19395438 |
2009 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results showed that the PSGL-1 deficiency inhibited the AS progression and regulated glucose metabolism, lipid metabolism, amino acid and phospholipid metabolism in LDLR<sup>-/-</sup> mice.
|
29483823 |
2018 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Taken together, binding of P-selectin to PSGL-1 on DCs contributes to atherosclerosis progression via DC activation via the TLR4 signaling pathway.
|
31263109 |
2019 |
|
Arteriosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest the impact of PSGL-1 Met62Ile polymorphism on inflammation in advanced atherosclerosis.
|
22307784 |
2012 |
|
Arteriosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart disease (CHD) and ischemic stroke among 13,875 participants in the prospective Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |
|
Atherosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results showed that the PSGL-1 deficiency inhibited the AS progression and regulated glucose metabolism, lipid metabolism, amino acid and phospholipid metabolism in LDLR<sup>-/-</sup> mice.
|
29483823 |
2018 |
|
Atherosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Taken together, binding of P-selectin to PSGL-1 on DCs contributes to atherosclerosis progression via DC activation via the TLR4 signaling pathway.
|
31263109 |
2019 |
|
Atherosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart disease (CHD) and ischemic stroke among 13,875 participants in the prospective Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |