|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Amyotrophic Lateral Sclerosis, Familial
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Taken together, binding of P-selectin to PSGL-1 on DCs contributes to atherosclerosis progression via DC activation via the TLR4 signaling pathway.
|
31263109 |
2019 |
|
Atherosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
Taken together, binding of P-selectin to PSGL-1 on DCs contributes to atherosclerosis progression via DC activation via the TLR4 signaling pathway.
|
31263109 |
2019 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results showed that the PSGL-1 deficiency inhibited the AS progression and regulated glucose metabolism, lipid metabolism, amino acid and phospholipid metabolism in LDLR<sup>-/-</sup> mice.
|
29483823 |
2018 |
|
Atherosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results showed that the PSGL-1 deficiency inhibited the AS progression and regulated glucose metabolism, lipid metabolism, amino acid and phospholipid metabolism in LDLR<sup>-/-</sup> mice.
|
29483823 |
2018 |
|
Arteriosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest the impact of PSGL-1 Met62Ile polymorphism on inflammation in advanced atherosclerosis.
|
22307784 |
2012 |
|
Atherosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest the impact of PSGL-1 Met62Ile polymorphism on inflammation in advanced atherosclerosis.
|
22307784 |
2012 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
|
19395438 |
2009 |
|
Atherosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
We therefore investigated the association of SELP polymorphisms with platelet SELP measures and polymorphisms in the SELPLG gene (selectin P ligand) with lymphocyte, granulocyte, and monocyte SELPLG measures among 1870 participants in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study.
|
19395438 |
2009 |
|
Arteriosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart disease (CHD) and ischemic stroke among 13,875 participants in the prospective Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |
|
Atherosclerosis
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart disease (CHD) and ischemic stroke among 13,875 participants in the prospective Atherosclerosis Risk in Communities (ARIC) study.
|
17420019 |
2007 |
|
Arteriosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
P-selectin and P-selectin glycoprotein ligand (SELPLG, selectin P ligand) constitute a receptor/ligand complex that is likely to be involved in the development of atherosclerosis and its complications.
|
14641238 |
2003 |
|
Atherosclerosis
|
0.060 |
Biomarker
|
disease |
BEFREE |
P-selectin and P-selectin glycoprotein ligand (SELPLG, selectin P ligand) constitute a receptor/ligand complex that is likely to be involved in the development of atherosclerosis and its complications.
|
14641238 |
2003 |
|
Hypertensive disease
|
0.050 |
Biomarker
|
group |
BEFREE |
PSGL1-deficient mice develop spontaneous pulmonary hypertension associated to systemic sclerosis.
|
31509349 |
2020 |
|
Hypertensive disease
|
0.050 |
Biomarker
|
group |
BEFREE |
Our results indicate that PSGL-1 is involved in the development of salt-sensitive hypertension via vascular inflammation and injury.
|
29541444 |
2018 |
|
Hypertensive disease
|
0.050 |
Biomarker
|
group |
BEFREE |
Angiotensin II-induced Hypertension is Reduced by Deficiency of P-selectin Glycoprotein Ligand-1.
|
29459637 |
2018 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
We report a case in which haemorrhagic oral bullae were the first sign of an undiagnosed primary systemic amyloidosis related to multiple myeloma IgG-λ and previously diagnosed CLA.
|
28247530 |
2017 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We showed the increase in Mac-1 expression along with a parallel decrease of L-selectin and PSGL-1 on peripheral blood neutrophils of patients with EOC of early and advanced FIGO stages, which indicates an activated state of neutrophils in comparison to neutrophils of individuals without cancer.
|
26563750 |
2016 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
We showed the increase in Mac-1 expression along with a parallel decrease of L-selectin and PSGL-1 on peripheral blood neutrophils of patients with EOC of early and advanced FIGO stages, which indicates an activated state of neutrophils in comparison to neutrophils of individuals without cancer.
|
26563750 |
2016 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
This study provides a better understanding of the biology of P-selectin and PSGL-1 and their roles in dissemination and resensitization of MM to treatment.
|
26539491 |
2015 |
|
Multiple Myeloma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to investigate the relationship between PSGL-1 expression in the bone marrow and the known prognostic factors for multiple myeloma disease, disease stage, and survival.
|
25445472 |
2015 |
|
Hypertensive disease
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Hypertension is associated with increased expression of FABP3, FAS, FN1, IL1R2, LPL, SERPINE1, TGFB1, and VCAM1 and decreased expression of SELPLG and SERPINEB2.
|
23337395 |
2014 |
|
Multiple Myeloma
|
0.050 |
Biomarker
|
disease |
BEFREE |
By profiling differentially regulated and paired plasma membrane protein genes, we showed that PSGL-1 (P-selectin glycoprotein ligand-1)/selectins and ICAM-1/CD18 played an important role in macrophage-mediated myeloma cell drug resistance, as blocking antibodies against these molecules or genetic knockdown of PSGL-1 or ICAM-1 in myeloma cells repressed macrophages' ability to protect myeloma cells.
|
22996336 |
2013 |