|
Vitamin K Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical value of LHPP-associated microRNAs combined with protein induced by vitamin K deficiency or antagonist-II in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma.
|
31693242 |
2020 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we aimed to investigate the role of LHPP in BC.
|
31262971 |
2019 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we aimed to investigate the role of LHPP in BC.
|
31262971 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers.
|
30912641 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers.
|
30912641 |
2019 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers.
|
30912641 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, whether LHPP is effective to melanoma has not been investigated.
|
31190803 |
2019 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we aimed to investigate the role of LHPP in BC.
|
31262971 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers.
|
30912641 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, LHPP could be considered as an effective candidate to develop effective therapeutic strategy against cervical cancer development.
|
29944886 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, suppressing p53 expression with its inhibitor of PFTα abrogated the activity of LHPP to impede cell proliferation and metastasis, and to trigger apoptosis.
|
29944886 |
2018 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, LHPP could be considered as an effective candidate to develop effective therapeutic strategy against cervical cancer development.
|
29944886 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Further, LHPP over-expression reduced the cell proliferation, migration and invasion, associated with the change of p53 and metastasis signaling pathways.
|
29944886 |
2018 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, LHPP could be considered as an effective candidate to develop effective therapeutic strategy against cervical cancer development.
|
29944886 |
2018 |
|
Sexually Transmitted Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, LHPP is a strong candidate to influence RSB and STD risk in the context of AD.
|
27531626 |
2017 |
|
Impulsive character (finding)
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, LHPP locus is associated to AD-RSB interaction; and with brain circuitries previously implicated in the inhibition of risky behavior and impulsiveness, emotional regulation, and impulse control/error monitoring.
|
27531626 |
2017 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Clinical value of LHPP-associated microRNAs combined with protein induced by vitamin K deficiency or antagonist-II in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma.
|
31693242 |
2020 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recent evidences have shown that Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) serves as a tumor suppressor in hepatocellular carcinoma and cervical cancer.
|
31262971 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Sustained, hepatic expression of LHPP in the hepatocellular carcinoma mouse model reduced tumour burden and prevented the loss of liver function.
|
29562234 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Recent evidences have shown that Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) serves as a tumor suppressor in hepatocellular carcinoma and cervical cancer.
|
31262971 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a novel tumor suppressor.
|
31190803 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In the present study, we discovered that LHPP expression levels were lower in human cervical cancer tumors than that in adjacent normal tissue samples.
|
29944886 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic.
|
29562234 |
2018 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |