|
Major Depressive Disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Since LHPP variants seem to be associated with the hippocampus, we assessed the relationship between rs35936514 variation and structural-functional connectivity within a hippocampal-corticolimbic neural system implicated in MDD.
|
31250265 |
2019 |
|
Major Depressive Disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
The present work explores whether the LHPP rs35936514 polymorphism moderates brain regional activity in MDD.
|
27843651 |
2016 |
|
Major Depressive Disorder
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10(-10)), the other in an intron of the LHPP gene (P = 6.45 × 10(-12)).
|
26176920 |
2015 |
|
Major Depressive Disorder
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 × 10(-10)), the other in an intron of the LHPP gene (P = 6.45 × 10(-12)).
|
26176920 |
2015 |
|
Major Depressive Disorder
|
0.340 |
Biomarker
|
disease |
PSYGENET |
LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations.
|
18268499 |
2009 |
|
Major Depressive Disorder
|
0.340 |
Biomarker
|
disease |
BEFREE |
LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations.
|
18268499 |
2009 |
|
Unipolar Depression
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder.
|
27843651 |
2016 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Sparse whole-genome sequencing identifies two loci for major depressive disorder.
|
26176920 |
2015 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations.
|
18268499 |
2009 |
|
Unipolar Depression
|
0.320 |
Biomarker
|
disease |
BEFREE |
LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations.
|
18268499 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.
|
27531626 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.110 |
Biomarker
|
disease |
BEFREE |
Thus, LHPP is a strong candidate to influence RSB and STD risk in the context of AD.
|
27531626 |
2017 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
|
29632299 |
2018 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.
|
27694927 |
2017 |
|
Alcohol-Related Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.
|
27531626 |
2017 |
|
Alcohol-Induced Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.
|
27531626 |
2017 |
|
Testicular Germ Cell Tumor
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.
|
28604732 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Recent evidences have shown that Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) serves as a tumor suppressor in hepatocellular carcinoma and cervical cancer.
|
31262971 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a novel tumor suppressor.
|
31190803 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In the present study, we discovered that LHPP expression levels were lower in human cervical cancer tumors than that in adjacent normal tissue samples.
|
29944886 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic.
|
29562234 |
2018 |