BLM, BLM RecQ like helicase, 641

N. diseases: 158; N. variants: 139
Disease: Prostate carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 GeneticVariation disease BEFREE Truncating BLM germline mutations occur at a higher frequency in patients with advanced prostate cancer as compared to control populations. 31816118 2020
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 PosttranslationalModification disease BEFREE In this study, we investigated whether BLM modulates the phosphorylation of an array of prooncogenic signaling pathways to promote PC progression. 31210839 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 AlteredExpression disease BEFREE The expression of BLM was significantly increased in PCa tissues and PC3 cells compared with non-PCa tissues and benign prostatic hyperplasia cells. 28943928 2017
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 GeneticVariation disease BEFREE (3) After prioritizing the candidate genes based on their similarity to known PC susceptibility genes, we found that seven novel PC susceptibility genes including BLM, RPS6KA2, FRK, ERBB4, RBL1, PAK7, and ERBB2IP. 25472581 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.050 GeneticVariation disease BEFREE To establish whether the Q548X allele of the BLM gene is present in Poland, and whether this allele predisposes to poor prognosis prostate cancer, we genotyped 3337 men with prostate cancer and 2604 controls. 24096176 2013