|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In order to investigate whether there was an interaction between a functional polymorphism in NKX3.1 that results in less protein and selenium status with prostate cancer grade or outcome, plasma selenium levels and the genotypes of NKX3.1 and the selenium carrier protein SELENOP were determined from a cohort of men who underwent radical protatectomy.
|
30582190 |
2019 |
|
Malignant neoplasm of prostate
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer.
|
29314169 |
2018 |
|
Malignant neoplasm of prostate
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Toenail selenium levels were inversely associated with advanced PCa risk, independently of common genetic variation in SEPP1 and GPX1.
|
24563517 |
2014 |
|
Malignant neoplasm of prostate
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We examined the association of SEPP1 single nucleotide polymorphisms (SNPs) with PCa risk and survival, and tested for interactions.
|
23129481 |
2013 |
|
Malignant neoplasm of prostate
|
0.380 |
Biomarker
|
disease |
BEFREE |
SNPs in GPX2, GPX3, GPX4, SEP15, and SEPP1 had different risk estimates for PCa in subgroups based on stage and grade.
|
23143801 |
2013 |
|
Malignant neoplasm of prostate
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, there was an association between rs7579 genotype in SEPP1 and prostate cancer risk (OR, 1.72; 95% CI, 0.99-2.98).
|
20852007 |
2010 |
|
Malignant neoplasm of prostate
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
In a low-selenium population, SOD2-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting prostate tumor cell proliferation and migration.
|
19074884 |
2008 |
|
Malignant neoplasm of prostate
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors.
|
12235003 |
2002 |
|
Malignant neoplasm of prostate
|
0.380 |
Biomarker
|
disease |
CTD_human |
Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors.
|
12235003 |
2002 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
We conclude that inflammation of the intestinal mucosa causes a decline in locally produced selenoprotein P in the colon that eventually may contribute to the emergence of inflammatory bowel disease-related colorectal cancer.
|
20542496 |
2010 |
|
Colorectal Carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that SNPs in SEPP1, GPX4 and SELS influence risk of CRC.
|
20378690 |
2010 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
An elevated proportion of the 60-kDa isoform of SePP may increase selenoprotein synthesis and reduce colorectal cancer risk.
|
19453253 |
2009 |
|
Colorectal Carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.
|
18483336 |
2008 |
|
Colorectal Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the expression of SePP and GI-GPx in colorectal cancers compared with corresponding normal mucosa.
|
15203372 |
2004 |
|
Adenoma
|
0.330 |
Biomarker
|
group |
CTD_human |
Three SNPs located in the 3' region of SEPP1, which is overlapping with the promoter region of an antisense transcript, were significantly associated with adenoma risk: homozygotes at two SEPP1 loci (31,174 bp 3' of STP A>G and 43,881 bp 3' of STP G>A) were associated with increased adenoma risk [odds ratio (OR), 1.48; 95% confidence interval (95% CI), 1.00-2.19 and OR, 1.53; 95% CI, 1.05-2.22, respectively] and the variant SEPP1 44,321 bp 3' of STP C>T was associated with a reduced adenoma risk (CT versus CC OR, 0.85; 95% CI, 0.63-1.15).
|
18483336 |
2008 |
|
Adenoma
|
0.330 |
GeneticVariation
|
group |
BEFREE |
Three SNPs located in the 3' region of SEPP1, which is overlapping with the promoter region of an antisense transcript, were significantly associated with adenoma risk: homozygotes at two SEPP1 loci (31,174 bp 3' of STP A>G and 43,881 bp 3' of STP G>A) were associated with increased adenoma risk [odds ratio (OR), 1.48; 95% confidence interval (95% CI), 1.00-2.19 and OR, 1.53; 95% CI, 1.05-2.22, respectively] and the variant SEPP1 44,321 bp 3' of STP C>T was associated with a reduced adenoma risk (CT versus CC OR, 0.85; 95% CI, 0.63-1.15).
|
18483336 |
2008 |
|
Adenoma
|
0.330 |
GeneticVariation
|
group |
LHGDN |
Three SNPs located in the 3' region of SEPP1, which is overlapping with the promoter region of an antisense transcript, were significantly associated with adenoma risk: homozygotes at two SEPP1 loci (31,174 bp 3' of STP A>G and 43,881 bp 3' of STP G>A) were associated with increased adenoma risk [odds ratio (OR), 1.48; 95% confidence interval (95% CI), 1.00-2.19 and OR, 1.53; 95% CI, 1.05-2.22, respectively] and the variant SEPP1 44,321 bp 3' of STP C>T was associated with a reduced adenoma risk (CT versus CC OR, 0.85; 95% CI, 0.63-1.15).
|
18483336 |
2008 |
|
Adenoma
|
0.330 |
AlteredExpression
|
group |
BEFREE |
Previously, we have demonstrated dramatically reduced SeP expression in human colon adenomas.
|
12173025 |
2002 |
|
Adenoma
|
0.330 |
Biomarker
|
group |
BEFREE |
It remains to be shown whether upregulation of gastrointestinal glutathione peroxidase in adenomas represents a compensatory mechanism to reduce susceptibility for oxidative damage resulting from the loss of selenoprotein P.
|
10965527 |
2000 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
In a low-selenium population, SOD2-Ala16+ men homozygous for SEPP1-Ala234 are at an increased risk of prostate cancer/aggressive prostate cancer especially if ever-smokers, because they are likely to produce more mitochondrial H(2)O(2) that they cannot remove, thereby promoting prostate tumor cell proliferation and migration.
|
19074884 |
2008 |
|
Prostatic Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Quantitative real-time reverse transcription-PCR for Selenoprotein-P demonstrated a similar down-regulation of the transcript of this gene in a subset of human prostate tumors, mouse tumors, and prostate carcinoma cell lines.
|
12235003 |
2002 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Quantitative real-time reverse transcription-PCR for Selenoprotein-P demonstrated a similar down-regulation of the transcript of this gene in a subset of human prostate tumors, mouse tumors, and prostate carcinoma cell lines.
|
12235003 |
2002 |
|
Malignant neoplasm of lung
|
0.310 |
Biomarker
|
disease |
BEFREE |
Our study of adult men living in selenium non-deficient areas in China provides little support for the inverse association between pre-diagnostic plasma SELENOP concentration and lung cancer risk.
|
30084959 |
2018 |
|
Neurodegenerative Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that SelP protects neuronal cells from Abeta-induced toxicity, suggesting a neuroprotective role for SelP in preventing neurodegenerative disorders.
|
20521393 |
2010 |
|
Malignant neoplasm of lung
|
0.310 |
Biomarker
|
disease |
CTD_human |
Expression of selenoprotein-coding genes SEPP1, SEP15 and hGPX1 in non-small cell lung cancer.
|
19058871 |
2009 |