|
Pulmonary Fibrosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings provide essential tools required to define the role of BH in BLM-induced pulmonary fibrosis and BLM resistance in tumors.
|
9331073 |
1997 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We find that BMH-21 significantly inhibited tumor growth and reduced the Ki67 proliferation index in an enzalutamide-resistant xenograft tumor model.
|
31524299 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
BMH-21 also decreased MDM2 proto-oncogene expression and increased protein levels of the tumor suppressor p53 and p53 phosphorylated at serine 15 (p‑p53‑Ser15), which contributed to increased expression of the downstream apoptosis-related protein BCL2 associated X (BAX) and activation of caspase-3.
|
28656213 |
2017 |
|
Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.
|
21943823 |
2011 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
These findings provide essential tools required to define the role of BH in BLM-induced pulmonary fibrosis and BLM resistance in tumors.
|
9331073 |
1997 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
No association was observed between carrying the BLMH-G genotype and AD in ε4 negative or positive subjects.
|
20198498 |
2010 |
|
Alzheimer's Disease
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that diminished functional BLH activity could contribute to the pathology of AD.
|
20308784 |
2010 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
LHGDN |
To further investigate, we have analyzed association between the apolipoprotein E (apo E) and bleomycin hydrolase (BH) polymorphisms and three groups of elderly patients: control subjects (T) (n = 68), late-onset sporadic DTA patients (DTAst) (n = 65) and other non vascular neurodegerative diseases (MNDA) (n = 52).
|
12604387 |
2003 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Additional studies should be undertaken to increase the confidence that the BH polymorphism is associated with AD and to explore the relationship between BH and apoE.
|
10822352 |
2000 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the genetic factors for AD among a Chinese population in Taiwan, we studied the polymorphisms of six candidate genes of Alzheimer's disease (AD), including the regulatory region of apolipoprotein E (Apo-E, G-186T), the promoter of apolipoprotein E (Apo-E, A-491T), the bleomycin hydrolase gene (BH, A1450G), a mutation of alpha(2)-macroglobulin gene (A2M G2998A), low-density lipoprotein receptor-related protein gene (LRP, C766T), and alpha(1)-antichymotrypsin gene (ACT, -15Ala/Thr) in AD patients and non-affected elder individuals among Taiwanese Chinese.
|
11099722 |
2000 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
However, no direct association was observed between the -491A/T or BH-PEN polymorphism and AD.
|
10530514 |
1999 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
These findings support a key proximal role for bleomycin hydrolase, and oxidative stress in AD.
|
10363952 |
1999 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In addition, apolipoprotein E gene allele E4 and the bleomycin hydrolase locus are shown to be genetic risk factors for late-onset AD in certain sporadic cases.
|
10230703 |
1999 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype.
|
9818937 |
1998 |
|
Narcolepsy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association database developed in the Japanese Integrated Database Project.
|
19629137 |
2009 |