SFRP2, secreted frizzled related protein 2, 6423

N. diseases: 134; N. variants: 0
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. 27042933 2016
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. 27261482 2016