Plasma SFRP5 levels are significantly lower in patients with obesity, insulin resistance and diabetes, a condition which contributes to the major components of the metabolic syndrome and to other disease conditions like atherosclerosis, autoimmune disorders, etc.
Significantly higher levels of Leptin and lower levels of Irisin, LGR4 and Sfrp5 were seen in patients with diabetes compared with non-diabetes (P < 0.05), the mean values of Leptin level was ascending and Irisin, LGR4, and Sfrp5 levels were declining with promoting of blood pressure in hypertension as compared to the non-hypertension with diabetic patients.