Significantly higher levels of Leptin and lower levels of Irisin, LGR4 and Sfrp5 were seen in patients with diabetes compared with non-diabetes (P < 0.05), the mean values of Leptin level was ascending and Irisin, LGR4, and Sfrp5 levels were declining with promoting of blood pressure in hypertension as compared to the non-hypertension with diabetic patients.
Plasma SFRP5 levels are significantly lower in patients with obesity, insulin resistance and diabetes, a condition which contributes to the major components of the metabolic syndrome and to other disease conditions like atherosclerosis, autoimmune disorders, etc.