SFRP5, secreted frizzled related protein 5, 6425

N. diseases: 106; N. variants: 0
Disease: Hepatitis B ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.020 Biomarker disease BEFREE Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway. 24374650 2014
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.020 Biomarker disease BEFREE SFRP methylation also was detected in hepatitis B or C virus-associated chronic hepatitis (SFRP1, 6/37, 16%; SFRP2, 14/37, 38%; SFRP5, 5/37, 14%) and liver cirrhosis (SFRP1, 10/28, 36%; SFRP2, 9/28, 32%; SFRP5, 3/28, 11%), suggesting that methylation of these genes is an early event in liver carcinogenesis. 18592156 2008