|
Amyotrophic Lateral Sclerosis
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In this study, we sequenced the entire coding sequence of ARHGEF28 in a Chinese cohort of 399 sporadic ALS and 327 elderly controls.
|
31060816 |
2020 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Rho guanine nucleotide exchange factor (RGNEF) is a novel NFL mRNA destabilizing factor that forms neuronal cytoplasmic inclusions in spinal motor neurons in both sporadic (SALS) and familial (FALS) ALS patients.
|
23286752 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Consistent with a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS), RGNEF forms pathological neuronal cytoplasmic inclusions in degenerating spinal motor neurons.
|
28495450 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown to co-aggregate with one another within motor neurons of sporadic ALS (sALS) patients, suggesting that there may be a common regulatory network disrupted.
|
28969660 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Furthermore, we observed RGNEF cytoplasmic inclusions in ALS spinal motor neurons that colocalized with ubiquitin, p62/sequestosome-1, and TAR (trans-active regulatory) DNA-binding protein 43 (TDP-43).
|
22835604 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer.
|
30482479 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort.
|
24712971 |
2014 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer.
|
30482479 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A xenograft mouse model was used to assess tumor growth and chemosensitivity to docetaxel in vivo in MDA-MB-231 cells with and without RIP2 small hairpin RNA knockdown.
|
24642040 |
2014 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Guanine nucleotide exchange factor T (GEFT), a member of the Rho guanine nucleotide exchange factor family, is expressed in a variety of tumors.
|
31620201 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer.
|
30482479 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In the case-only study, an association between an RIP2 promoter polymorphism and childhood severe asthma (P=0.0032; odds ratio (OR) 3.37, 95% confidence interval (CI) 1.45-7.87) was observed.
|
17075290 |
2006 |
|
Asthma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The situation is complicated further by the fact that WT NOD2 and WT RIP2 activity has been implicated in diseases such as asthma, inflammatory arthritis and MS.
|
23794710 |
2013 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity.
|
21236705 |
2011 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
RIP2 kinase was recently identified as a therapeutic target for a variety of autoimmune diseases.
|
30344914 |
2018 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, the expression of zebrafish histone H2A was decreased by RIP2 deficiency with and/or without bacterial infection.
|
31336107 |
2019 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Collectively, these findings demonstrate that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autophagy and inflammatory signaling in response to bacterial infection.
|
24746552 |
2014 |
|
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
NOD1, RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression.
|
24817964 |
2014 |
|
Squamous cell carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we find that in vivo, the α-catenin homologue-α-catulin, a protein originally reported to interact with Lbc Rho guanine nucleotide exchange factor, is highly expressed at the tumor invasion front and in the metastatic streams of cells in both malignant hHNSCCs and a mouse model of oral SCC.
|
22648798 |
2012 |
|
Crohn Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
The present study is aimed at describing the downstream events triggered specifically by NOD2 induction in order to demonstrate that the protein, other than overexpressed, is also physiologically associated with RIP2 and Erbin in the bioptic intestinal inflamed specimens of children affected by CD.
|
19266573 |
2009 |