|
Amyotrophic Lateral Sclerosis
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In this study, we sequenced the entire coding sequence of ARHGEF28 in a Chinese cohort of 399 sporadic ALS and 327 elderly controls.
|
31060816 |
2020 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer.
|
30482479 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Consistent with a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS), RGNEF forms pathological neuronal cytoplasmic inclusions in degenerating spinal motor neurons.
|
28495450 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Out of these RNA-binding proteins, TDP-43, FUS/TLS and RGNEF have been shown to co-aggregate with one another within motor neurons of sporadic ALS (sALS) patients, suggesting that there may be a common regulatory network disrupted.
|
28969660 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28.
|
27154192 |
2016 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort.
|
24712971 |
2014 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Rho guanine nucleotide exchange factor (RGNEF) is a novel NFL mRNA destabilizing factor that forms neuronal cytoplasmic inclusions in spinal motor neurons in both sporadic (SALS) and familial (FALS) ALS patients.
|
23286752 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
0.370 |
Biomarker
|
disease |
BEFREE |
Furthermore, we observed RGNEF cytoplasmic inclusions in ALS spinal motor neurons that colocalized with ubiquitin, p62/sequestosome-1, and TAR (trans-active regulatory) DNA-binding protein 43 (TDP-43).
|
22835604 |
2013 |
|
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
|
23509962 |
2013 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer.
|
30482479 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Guanine nucleotide exchange factor T (GEFT), a member of the Rho guanine nucleotide exchange factor family, is expressed in a variety of tumors.
|
31620201 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer.
|
30482479 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
A xenograft mouse model was used to assess tumor growth and chemosensitivity to docetaxel in vivo in MDA-MB-231 cells with and without RIP2 small hairpin RNA knockdown.
|
24642040 |
2014 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
A total of six breast cancer expression databases, including The Cancer Genome Atlas, were assessed for RIP2 expression among various clinical subtypes and its role as a prognostic biomarker. mRNA fluorescence in situ hybridization (FISH) for RIP2 was performed on 17 stage III breast cancers to determine if there was a correlation between RIP2 expression and lymph node involvement.
|
24642040 |
2014 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, the expression of zebrafish histone H2A was decreased by RIP2 deficiency with and/or without bacterial infection.
|
31336107 |
2019 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
RIP2 kinase was recently identified as a therapeutic target for a variety of autoimmune diseases.
|
30344914 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Receptor‑interacting protein 2 (RIP2) has recently been reported to be involved in tumor infiltration and cancer metastasis.
|
29693188 |
2018 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Collectively, these findings demonstrate that NOD1 detects PG within early endosomes, thereby promoting RIP2-dependent autophagy and inflammatory signaling in response to bacterial infection.
|
24746552 |
2014 |
|
Squamous cell carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
NOD1, RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression.
|
24817964 |
2014 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
These results highlight RIP2 as a pro-metastasis kinase in patients with advanced breast cancer.
|
24642040 |
2014 |