|
TOOTH AGENESIS, SELECTIVE, 9
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
GREMLIN 2 Mutations and Dental Anomalies.
|
26416033 |
2015 |
|
TOOTH AGENESIS, SELECTIVE, 9
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
TOOTH AGENESIS, SELECTIVE, 9
|
0.600 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Cytokine Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study of antibody response to smallpox vaccine.
|
22542470 |
2012 |
|
Selective tooth agenesis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Agenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Fourteen variants in/nearby WNT10A, WNT10B and GREM2 were genotyped to test for association with tooth agenesis.
|
30246922 |
2018 |
|
Agenesis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
GREM2 nucleotide variants and the risk of tooth agenesis.
|
28992378 |
2018 |
|
Agenesis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here, we demonstrate for the first time that GREM2 mutations are associated with human malformations, which include isolated tooth agenesis, microdontia, short tooth roots, taurodontism, sparse and slow-growing hair, and dry and itchy skin.
|
26416033 |
2015 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the expression and the role of Grem2 in the development of renal lesions in mice with type 2 DN.
|
30831151 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Based on the <i>in silico</i> analysis of GSE49051, GREM2 was determined to be overexpressed in GC and its expression was the highest in the MKN-45 cell line, which was selected for the subsequent experiments.
|
31345097 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gremlin-1 and gremlin-2 levels in polycystic ovary syndrome and their clinical correlations.
|
30712421 |
2019 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, the aforementioned findings suggest that the silencing of GREM2 suppresses the activation of the JNK signaling pathway, thereby inhibiting tumor progression.
|
31345097 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Silencing of GREM2 or inhibition of the JNK signaling pathway suppressed the proliferation, migration and invasion, while promoting apoptosis of GCSCs <i>in vitro</i> as well as inhibiting tumorigenesis and lymph node metastasis <i>in vivo</i>.
|
31345097 |
2019 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Based on the <i>in silico</i> analysis of GSE49051, GREM2 was determined to be overexpressed in GC and its expression was the highest in the MKN-45 cell line, which was selected for the subsequent experiments.
|
31345097 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Silencing of GREM2 or inhibition of the JNK signaling pathway suppressed the proliferation, migration and invasion, while promoting apoptosis of GCSCs <i>in vitro</i> as well as inhibiting tumorigenesis and lymph node metastasis <i>in vivo</i>.
|
31345097 |
2019 |
|
Hypodontia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The previously described, functional GREM2 mutation (c.226C > G, p.Gln76Glu) was identified in two patients with hypodontia and associated dental anomalies, including taurodontism and microdontia.
|
28992378 |
2018 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Grem2 enhances the protective effect of CPCs on heart function in a mouse model of MI, suggesting its potential as the rapeutic protein for cardiac repair.
|
29794428 |
2018 |
|
Microdontia (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The previously described, functional GREM2 mutation (c.226C > G, p.Gln76Glu) was identified in two patients with hypodontia and associated dental anomalies, including taurodontism and microdontia.
|
28992378 |
2018 |
|
Taurodontism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The previously described, functional GREM2 mutation (c.226C > G, p.Gln76Glu) was identified in two patients with hypodontia and associated dental anomalies, including taurodontism and microdontia.
|
28992378 |
2018 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo, Grem2 silencing abolished the protective effects of CPC injection on cardiac fibrosis and function.
|
29794428 |
2018 |
|
Oligodontia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Direct sequencing of the GREM2 coding sequence including exon/intron boundaries was performed in 95 patients with both hypodontia and oligodontia.
|
28992378 |
2018 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Here, we demonstrate for the first time that GREM2 mutations are associated with human malformations, which include isolated tooth agenesis, microdontia, short tooth roots, taurodontism, sparse and slow-growing hair, and dry and itchy skin.
|
26416033 |
2015 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this cohort, we identified novel loci genome-wide significantly associated as modifiers of the age of onset of AD (CD44, rs187116, P=1.29 × 10⁻¹²; NPHP1, rs10173717, P=1.74 × 10⁻¹²; CADPS2, rs3757536, P=1.54 × 10⁻¹⁰; GREM2, rs12129547, P=1.69 × 10⁻¹³, among others) as well as other loci known to be associated with AD.
|
22710270 |
2013 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
GREM2 overactivity results in slower cardiac contraction rates in zebrafish, and induction of previously identified AF candidate genes encoding connexin-40, sarcolipin and atrial natriuretic peptide in differentiated mouse embryonic stem cells.
|
23223679 |
2013 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis.
|
23902946 |
2013 |