HHIP, hedgehog interacting protein, 64399

N. diseases: 122; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.420 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.420 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.420 Biomarker disease CTD_human Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.420 GeneticVariation disease BEFREE The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. 12632100 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.420 Biomarker disease BEFREE HIP is a candidate marker of abnormal cell growth in the colon and a prognostic marker for colorectal carcinoma. 10383165 1999
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 GeneticVariation group GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker group CTD_human Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 GeneticVariation group GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 AlteredExpression disease BEFREE A novel long noncoding RNA HHIP-AS1 suppresses hepatocellular carcinoma progression through stabilizing HHIP mRNA. 31604528 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 PosttranslationalModification disease LHGDN We analyzed the involvement of Hh-interacting protein (HHIP) gene, a negative regulator of Hh signaling, in HCC. 18559595 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 Biomarker disease CTD_human We analyzed the involvement of Hh-interacting protein (HHIP) gene, a negative regulator of Hh signaling, in HCC. 18559595 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.320 Biomarker disease BEFREE We analyzed the involvement of Hh-interacting protein (HHIP) gene, a negative regulator of Hh signaling, in HCC. 18559595 2008
CUI: C0848558
Disease: Hypospadias
Hypospadias 		0.300 Biomarker disease CTD_human Di-n-butyl phthalate induced autophagy of uroepithelial cells via inhibition of hedgehog signaling in newborn male hypospadias rats. 31568847 2019
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.300 Biomarker group CTD_human Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. 27793025 2016
CUI: C3179349
Disease: Gastrointestinal Stromal Sarcoma
Gastrointestinal Stromal Sarcoma 		0.300 Biomarker disease CTD_human Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. 27793025 2016
CUI: C3495676
Disease: Anorectal Malformations
Anorectal Malformations 		0.300 Biomarker group GENOMICS_ENGLAND Hedgehog gene polymorphisms are associated with the risk of Hirschsprung's disease and anorectal malformation in a Chinese population. 27082974 2016
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.200 Biomarker group RGD The role of hedgehog-interacting protein in maintaining cavernous nerve integrity and adult penile morphology. 19515211 2009
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.200 Biomarker disease RGD The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. 18375471 2008
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.200 Biomarker disease RGD The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. 18375471 2008
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.120 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.120 GeneticVariation disease GWASCAT Association analyses identify 31 new risk loci for colorectal cancer susceptibility. 31089142 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.120 AlteredExpression disease BEFREE Down-regulation of HHIP expression by siRNA resulted in a significant increase in colon cancer cell growth and invasion in vitro. 17724792 2007
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.120 Biomarker disease BEFREE In the current study, we contrast the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on the HCT8 colon cancer cell lines to the HCT116 and FET cell lines wherein PAC1 is expressed as the SV1 or HIP splice variant and is coupled to the activation only of cAMP but not of intracellular Ca2+. 14742913 2004
CUI: C0005612
Disease: Birth Weight
Birth Weight 		0.100 GeneticVariation phenotype GWASCAT Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. 31043758 2019
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019