|
Asthma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
O<sub>3</sub> induced significant BAL fluid neutrophilia and eosinophilia and increased AHR and expression of IL6 and IL25 mRNA in the airway epithelium together with increased BAL fluid group 2 innate lymphoid cell (ILC2s), CD1c<sup>+</sup> myeloid dendritic cell, and CD4<sup>+</sup> T-cell counts and diminished surfactant protein D expression.
|
31627909 |
2020 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
High surfactant protein D (SP-D) concentrations in cord blood of IUGR foetuses/neonates could point to structural lung immaturity, resulting to asthma and chronic obstructive pulmonary disease in adult life.
|
31577039 |
2019 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
Met11Thr variation strongly affected serum SP-D levels and the degree of multimerization, but was not associated with COPD and asthma in the study.
|
28960651 |
2018 |
|
Asthma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Expression of SP-D was examined in human airway sections and primary airway epithelial cells (AEC) grown in air-liquid interface (ALI) cultures and comparisons were made between those from asthmatic and non-asthmatic donors.
|
25848896 |
2015 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model.
|
24712849 |
2014 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Here, we examine this link between IL-13 and SP-D, and its implications in the progression/regulation of asthma and allergy.
|
23220073 |
2013 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
RGD |
Increased surfactant protein a and d expression in acute ovalbumin-induced allergic airway inflammation in brown norway rats.
|
18802356 |
2009 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
LHGDN |
Taken together, these results support the hypothesis that SP-D-dependent innate immunity influences atopy and asthma.
|
18355911 |
2008 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages.
|
18628238 |
2008 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism in the SFTPD gene, affecting SP-D levels and pathogen binding, was associated with decreased atopy in black subjects and potentially lower asthma susceptibility in white subjects.
|
18355911 |
2008 |
|
Asthma
|
0.290 |
GeneticVariation
|
disease |
LHGDN |
Amino acid variants in Surfactant protein D are not associated with bronchial asthma.
|
16426259 |
2006 |
|
Asthma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Due to its function SFTPD represents an ideal candidate gene for bronchial asthma and we were interested whether the polymorphisms were in association with asthma in children.
|
16426259 |
2006 |