|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
bcr-3 transcript has a more lethal outcome and is also associated with frequent relapse risk in APL patients of our region.
|
30803552 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we describe a case of APL with high white blood cell counts in blood tests and hypogranular variant morphology in bone marrow, together with fms-like tyrosine kinase-3 with internal tandem duplication mutations (FLT3-ITD), and bcr-3 isoform of PML-RARα.
|
28125133 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several additional promyelocytic/retinoic acid receptor-alpha (PML/RARalpha) transcripts besides bcr1, bcr2, and bcr3 have been identified in patients with acute promyelocytic leukemia (APL).
|
19863682 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To the best of our knowledge, this is the first report of an APL with a bcr3/short form PML-RARalpha transcript generated from derivative chromosome 17 due to submicroscopic insertion of the PML gene into the RARalpha locus.
|
19095567 |
2009 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
At diagnosis, cytogenetic analysis failed to reveal any karyotypic abnormality; however, a promyelocytic leukemia-retinoic acid receptor alpha (PML/RARA) fusion transcript of the bcr3-type was detected with reverse transcriptase-polymerase chain reaction analysis, and a single PML/RARA fusion signal was observed with fluorescence in situ hybridization analysis.
|
15036889 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PML/RARalpha fusion gene in acute promyelocytic leukaemia (APL) has three subtypes based on the breakpoint site of the PML gene: long (bcr1), short (bcr3) and variable (bcr2) subtypes.
|
12899711 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiplex RT-PCR analysis showed that the L-form (BCR1) and S-form (BCR3) were correlated with CD34(-) APL and CD34(+) APL, respectively.
|
12827650 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The majority of patients with acute promyelocytic leukemia (APL) possess either a bcr1 or a bcr3 type fusion between PML and RARalpha genes.
|
10720132 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this report, we investigated the biological role of a bcr-3 isoform of RARalpha-PML for the development of APML in a transgenic mouse model.
|
10611345 |
1999 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, the pml/RARalpha fusion protein present in acute promyelocytic leukemia presents no binding motif (BCR 3) at all or to a single HLA molecule (Cw*0301, BCR 1).
|
9815736 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The bcr1- and bcr3- promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) are the two major fusion proteins expressed in acute promyelocytic leukemia (APL) patients.
|
9242550 |
1997 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is concluded that APL in children did not differ significantly from the adult form, with the exception of a higher incidence of PML bcr3 breakpoint.
|
7815842 |
1994 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular studies on a large series of APLs revealed great heterogeneity of the PML/RAR alpha transcripts due to: (i) variable breaking of chromosome 15 within three PML breakpoint cluster regions (bcr1, bcr2 and bcr3), (ii) alternative splicings of the PML portion and (iii) alternative usage of two RAR alpha polyadenylation sites.
|
1314166 |
1992 |