Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
Memory, Short-Term
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-Wide Association Study of Latent Cognitive Measures in Adolescence: Genetic Overlap With Intelligence and Education.
|
31598132 |
2019 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Defining the role of common variation in the genomic and biological architecture of adult human height.
|
25282103 |
2014 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of ten loci associated with height highlights new biological pathways in human growth.
|
18391950 |
2008 |
Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Identification of ten loci associated with height highlights new biological pathways in human growth.
|
18391950 |
2008 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Conversely, overexpression of SH3GL3 increased myeloma cells migration/invasion.
|
27683032 |
2016 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
From these, we confirmed the genes encoding cadherin-11 (CDH11), proprotein convertase subtilisin/kexin type 6 (PCSK6) and SH3-domain GRB2-like 3 (SH3GL3) as novel glioma invasion-associated candidate genes, with knockdown of PCSK6 and SH3GL3 inhibiting glioma cell invasion, while inhibition of CDH11 promoted glioma cell invasion in vitro.
|
21722156 |
2012 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
|
29920278 |
2018 |
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of a subset of genes (ASCL2, KCNA1, SH3GL3, SRD5A2) in ALL is confirmed by measuring 20 patient samples using pyrosequencing.
|
30192066 |
2018 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
|
29920278 |
2018 |
Neurodegenerative Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Bioinformatics analyses revealed that endophilin-3 expresses at a significantly lower level in neurodegenerative diseases.
|
30049645 |
2018 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
|
29920278 |
2018 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After network module analysis, MYC, FGFR1 and HOXA10 were selected as the up-regulated coexpressed genes in the gliomas and glioblastoma, while SH3GL3 and SNRPN were selected as the down-regulated coexpressed genes in the gliomas and glioblastoma.
|
28952134 |
2017 |
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After network module analysis, MYC, FGFR1 and HOXA10 were selected as the up-regulated coexpressed genes in the gliomas and glioblastoma, while SH3GL3 and SNRPN were selected as the down-regulated coexpressed genes in the gliomas and glioblastoma.
|
28952134 |
2017 |
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After network module analysis, MYC, FGFR1 and HOXA10 were selected as the up-regulated coexpressed genes in the gliomas and glioblastoma, while SH3GL3 and SNRPN were selected as the down-regulated coexpressed genes in the gliomas and glioblastoma.
|
28952134 |
2017 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After network module analysis, MYC, FGFR1 and HOXA10 were selected as the up-regulated coexpressed genes in the gliomas and glioblastoma, while SH3GL3 and SNRPN were selected as the down-regulated coexpressed genes in the gliomas and glioblastoma.
|
28952134 |
2017 |
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that SH3GL3 plays an important role in myeloma cell migration/invasion, stemness and chemo-resistance.
|
27683032 |
2016 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, three genes that exhibited hypermethylation in their promoter regions, CMTM2, ECRG4, and SH3GL3, were shown to be significantly associated with colorectal cancer in previous studies.
|
22901147 |
2012 |
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using molecular profiling of microdissected primary tumour tissue specimens followed by functional in vitro analysis, we identified and validated CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes that likely contribute to the invasive phenotype of malignant gliomas.
|
21722156 |
2012 |
Malignant Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using molecular profiling of microdissected primary tumour tissue specimens followed by functional in vitro analysis, we identified and validated CDH11, PCSK6 and SH3GL3 as novel glioma invasion-associated candidate genes that likely contribute to the invasive phenotype of malignant gliomas.
|
21722156 |
2012 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, three genes that exhibited hypermethylation in their promoter regions, CMTM2, ECRG4, and SH3GL3, were shown to be significantly associated with colorectal cancer in previous studies.
|
22901147 |
2012 |
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The characteristics of the interaction between SH3GL3 and huntingtin and the colocalization of the two proteins suggest that SH3GL3 could be involved in the selective neuronal cell death in HD.
|
9809064 |
1998 |