|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
rs6259 and rs3760213 SNPs are associated with the risk of MetS and lower serum SHBG level in Chinese Han males.
|
24671943 |
2014 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This relationship was also observed in MetS components (BMI and SBP).
|
30157802 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
To examine whether expression of human <i>SHBG</i> in mice may ameliorate the development of diabetes and metabolic syndrome in response to a high-fat diet (HFD).
|
29141991 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013.
|
29245159 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AChE activity was associated with BP status and SBP, whereas BChE activity was associated with features of the metabolic syndrome (especially body weight and BMI).
|
21493754 |
2011 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides, sex, age, WC, SBP, DBP, ALT, FG, UAC, TG, HDL-C and LDL-C are risk factors for MetS after multivariate adjustment.
|
28740055 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, this body of evidence indicates that sex steroids and SHBG should be routinely incorporated into clinical characterization of T2D patients, particularly in screening prediabetic patients, such as those with metabolic syndrome, using plasma levels of SHBG.
|
27990781 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to identify and summarize the relationships between muscular fitness (MF) and individual components of metabolic syndrome (high waist circumference [WC], high blood pressure [BP], high systolic BP [SBP], high diastolic BP [DBP], high triglycerides [TG], fasting blood glucose [FG], and low HDL cholesterol levels [HDL-C]) in children and adolescents.
|
30273286 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Correlations between the levels of biochemical parameters and the levels of hormones in serum and the prostate tissue of BPH patients with and without MetS demonstrate that serum SHBG levels correlated weakly with waist size and triglyceride levels.
|
30122909 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Testosterone (free and total) and SHBG were significantly lower in MetS subjects and modestly reduced in type 2 DM with and without MetS.
|
30057912 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.
|
28577342 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
MetS patients had lower levels of total testosterone (P = 0.001), sex hormone-binding globulin, inhibin B, and anti-Mόllerian hormone (all P ≤ 0.03), and they were hypogonadal at a higher prevalence (P = 0.01) than patients without MetS.
|
27004539 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This SHBG decrease is more pronounced in girls with premature pubarche who are at risk to develop functional ovarian hyperandrogenism as well as insulin resistance syndrome.
|
11117669 |
2000 |
|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status.
|
25647406 |
2015 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome.
|
30478933 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SHBG mRNA and protein levels were lower in patients with metabolic syndrome than in those without metabolic syndrome; however, these differences were significant only for mRNA level.
|
30496542 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low plasma sex hormone-binding globulin (SHBG) levels in overweight individuals are a biomarker for the metabolic syndrome and are predictive of type 2 diabetes and cardiovascular disease risk.
|
26441241 |
2015 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low endogenous testosterone and sex hormone-binding globulin (SHBG) concentrations have been reported to be associated with metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD).
|
31068503 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Eight of them were normotensive and eleven hypertensive according to MetS threshold (≥130 mmHg for SBP and/or ≥85 mmHg for DBP).
|
28493030 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lower levels of sex hormone-binding globulin increase risks of MetS and T2DM in both sexes.
|
29241756 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the allele frequencies of SHBG gene polymorphisms in relation to the risk components of MetS.
|
23788303 |
2013 |
|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among the subjects who developed the MetS those with the Pro12Pro genotype (n = 3) had significantly lower levels of SHBG compared to subjects with X12Ala (n = 8) (13.23 vs 28 nmol/L, p = 0.025).
|
17322577 |
2006 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Simple logistic analysis showed that sex (OR 3.50, 95% CI 1.21-10.12, p = 0.021), age (OR 1.14, 95% CI 1.07-1.21, p<0.001), BMI (OR 1.11, 95% CI 1.01-1.22, p = 0.028), waist circumference (OR 1.06, 95% CI 1.02-1.10, p = 0.002), SBP (OR 1.03, 95% CI 1.01-1.04, p = 0.003), DBP (OR 1.03, 95% CI 1.00-1.06, p = 0.030), HDL-C (OR 0.97, 95% CI 0.94-1.00, p = 0.026), uric acid (OR 1.84, 95% CI 1.49-2.27, p<0.001), metabolic syndrome (OR 2.68, 95% CI 1.29-5.67, p = 0.009), and decreased BMD (OR 3.998, 95% CI 1.38-11.57, p = 0.011) were significantly associated with CKD.
|
29320555 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies to assess the association between VD and MetS or its components (systolic blood pressure [SBP], diastolic blood pressure [DBP], fasting glucose triglycerides, waist circumference [WC], HDL-cholesterol (HDL-C)) in adults.
|
29907356 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Baseline characteristics were similar in the two SBP target groups within each MetS subgroup, except body mass index was slightly higher in the standard arm of the MetS subgroup (33.3 ± 5.6 vs 33.0 ± 5.3 kg/m<sup>2</sup> ; P < .01), but were similar across treatment arms in the non-MetS subgroup.
|
29024310 |
2018 |