|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
This degradation pathway is Siah-1 and adenomatous polyposis colidependent, but glycogen synthase kinase-3beta and F-box beta-transducin repeat-containing protein-independent.
|
16735606 |
2006 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
Two adenomatous polyposis coli (APC)-dependent proteasomal degradation pathways, one involving glycogen synthase kinase 3beta (GSK3beta) and the other involving p53-Siah-1, degrade excess beta-catenin in normal cells.
|
15190077 |
2004 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
|
30323224 |
2018 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death.
|
30796178 |
2019 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, the role of siah‑1 was investigated in the nuclear translocation of GAPDH in rat C6 astroglioma cells treated with Hcy.
|
31322210 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We have reported that SIAH1 is down-regulated and associated with apoptosis and invasion in human breast cancer.
|
25851994 |
2016 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we re-evaluated the effects of SIAH1 and SIAH2 depletion in breast cancer cell lines, focusing on migration and invasion.
|
26654769 |
2015 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The status of Siah1 and Siah1L was analysed in five breast cancer cell lines.
|
20682032 |
2010 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Thus, Siah1 is implicated in the regulation of HIF1alpha and is involved in a recently appreciated aspect of EBV-mediated tumorigenesis, namely, the angiogenesis process triggered by LMP1.
|
17047048 |
2006 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.
|
12810624 |
2003 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The inhibition of SIAH1 is in line with the notion that EBV impedes various pro-apoptotic pathways during tumorigenesis.
|
21062812 |
2011 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis.
|
25110433 |
2014 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Therefore, <i>Tp53</i> mutation-Siah1-WISP1 is a new signaling pathway, playing an important role in pancreatic carcinogenesis.
|
30123132 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
These observations suggest SIAH1 as a candidate tumor suppressor gene that may be inactivated during tumorigenesis.
|
10956387 |
2000 |
|
Carcinoma, Basal Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, several parameters distinguish MGC from BCC samples: (i) the mRNA level of the shelterin subunits decreased in MGC but it increased in BCC; (ii) P53 was more highly mutated in MGC; (iii) Siah1 mRNA was over-expressed in BCC; (iv) BCC samples contain a higher level of senescent cells; (v) Ki-67 and Bcl2 expression were lower in BCC.
|
26437300 |
2016 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.
|
29217406 |
2018 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, miR-135a/SIAH1/β-catenin signaling is important in the transformation and progression of cervical carcinoma.
|
24503442 |
2014 |
|
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
|
30323224 |
2018 |
|
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death.
|
30796178 |
2019 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.
|
29217406 |
2018 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A rapid real-time quantitative RT-PCR fluorescent method shows that SIAH1 remained transcriptionally active in the 6 colon cancer-derived cell lines, and the expression is comparable to the normal colon tissue.
|
10956387 |
2000 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical analysis showed that m<sup>6</sup>A can regulate the expression of RP11, further, RP11 regulated Siah1-Fbxo45/Zeb1 was involved in the development of CRC.
|
30979372 |
2019 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Remarkably, coexpression of Siah1 with Akt3-WT restricted disorganization of neural development is caused by Akt3 overexpression, whereas forced expression of Siah1 with the Akt3-E17K mutant fails to cope with malformation of neural development.
|
31471318 |
2019 |
|
Conn Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, SIAH1 sequence variants were identified in patients with PA; such variants impaired SIAH1 ubiquitin ligase activity, resulting in elevated PIAS1 expression.
|
29212953 |
2017 |