|
Deformity
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Remarkably, coexpression of Siah1 with Akt3-WT restricted disorganization of neural development is caused by Akt3 overexpression, whereas forced expression of Siah1 with the Akt3-E17K mutant fails to cope with malformation of neural development.
|
31471318 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of SIAH1 protein in DLBCL was demonstrated by immunohistochemistry.
|
21062812 |
2011 |
|
Experimental Organism Basal Cell Carcinoma
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
However, several parameters distinguish MGC from BCC samples: (i) the mRNA level of the shelterin subunits decreased in MGC but it increased in BCC; (ii) P53 was more highly mutated in MGC; (iii) Siah1 mRNA was over-expressed in BCC; (iv) BCC samples contain a higher level of senescent cells; (v) Ki-67 and Bcl2 expression were lower in BCC.
|
26437300 |
2016 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
|
30323224 |
2018 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A database analysis revealed that SIAH1, but not SIAH2, is significantly overexpressed in glioblastomas.
|
30796178 |
2019 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.
|
30323224 |
2018 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death.
|
30796178 |
2019 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that Siah1 plays important roles in the migration and invasion of human glioma cells under hypoxia, which may provide some guidance for the targeted therapy of human glioma based on the interference of the Siah1-PHD3-HIF-1α signaling pathway.
|
25572001 |
2015 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.
|
28481365 |
2017 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
The effects of HBx on p53 and Siah-1 were exactly reproduced in a 1.2-mer HBV replicon system, mimicking the natural course of HBV infection.
|
28714848 |
2017 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
E3 ubiquitin ligase Siah-1 facilitates poly-ubiquitylation and proteasomal degradation of the hepatitis B viral X protein.
|
21878328 |
2011 |
|
Hepatocarcinogenesis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SIAH-1 expression was analyzed at the transcript and protein levels in human hepatocarcinogenesis and in HCC cells.
|
21356256 |
2011 |
|
Hyperaldosteronism
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data identify a role for the Siah1-PIAS1 axis in adrenal gland organization and function and point to possible therapeutic targets for hyperaldosteronism.
|
29212953 |
2017 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore, Siah-1 may play important roles in ubiquitin-dependent degradation of HBx and may be involved in suppressing the progression of hepatocellular carcinoma (HCC).
|
21878328 |
2011 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
LHGDN |
Therefore we conclude that distinct SIAH-1 levels mediate pro-tumorigenic effects in HCC cells and that further SIAH-1 inhibition may represent a new therapeutic strategy in the treatment of human hepatocellular carcinoma.
|
18314624 |
2007 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Because the nuclear pattern of SIAH-2 differs in HCC tissues from the SIAH-1 pattern and because the inactivation of SIAH-2 is not compensated by SIAH-1, the specific inhibition of SIAH-2 (especially in combination with other drugs) represents a promising therapeutic strategy for HCC.
|
22323152 |
2012 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
RNA interference revealed that nuclear expression of SIAH-1 predominantly supported HCC cell proliferation and migration while only moderately affecting anti-apoptosis.
|
21356256 |
2011 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
LHGDN |
SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages.
|
12557228 |
2003 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages.
|
12557228 |
2003 |
|
Malignant Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression level and functional significance of Siah1 in human malignant glioma, which is characterized by high migration and invasion potential, have never been investigated.
|
25572001 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
The status of Siah1 and Siah1L was analysed in five breast cancer cell lines.
|
20682032 |
2010 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we re-evaluated the effects of SIAH1 and SIAH2 depletion in breast cancer cell lines, focusing on migration and invasion.
|
26654769 |
2015 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We have reported that SIAH1 is down-regulated and associated with apoptosis and invasion in human breast cancer.
|
25851994 |
2016 |
|
Malignant neoplasm of oropharynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine whether Siah-1 is important for the proteasomal degradation of beta-catenin in HPV16-positive oropharyngeal cancer cells, we introduced a Siah-1 expression vector into 147T and 090 cells and found substantial reduction of endogenous beta-catenin in these cells.
|
20215420 |
2010 |