|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.
|
26028498 |
2015 |
|
Malignant neoplasm of stomach
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that inactivating mutations of the Siah-1 may contribute to the development of gastric cancer through beta-catenin stabilization and apoptosis block.
|
15467739 |
2004 |
|
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, this work delineated the role of Siah1 in increasing invasiveness of H. pylori-infected GCCs.
|
28481365 |
2017 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We find that SIAH1 and SIAH2 are expressed in all human epithelial cell lines examined thus far, while SIAH3 is only expressed in a limited subset of cancer cell lines.
|
28784114 |
2017 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
A rapid real-time quantitative RT-PCR fluorescent method shows that SIAH1 remained transcriptionally active in the 6 colon cancer-derived cell lines, and the expression is comparable to the normal colon tissue.
|
10956387 |
2000 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, SIAH1 was upregulated in 75 % of miR-944-deficient breast tumors.
|
27377268 |
2016 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.
|
30771432 |
2019 |
|
Nasopharyngeal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis.
|
23228635 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, Siah-1 appears to be correlated with clinicopathological data, particularly tumor size.
|
27616748 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We report here, that Siah1 was expressed highly in human glioma tissues compared with its expression in normal brain tissues and was correlated with advanced tumor status and stage.
|
25572001 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca(2+) ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
|
21947242 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).
|
10393949 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nuclear accumulation of the E3 ubiquitin ligase SIAH-1 supports different pro-tumorigenic cellular processes associated with tumor growth and tumor cell dissemination in human hepatocarcinogenesis.
|
21356256 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIAH1 and SIAH2 have been found to function as a tumour repressor and a proto-oncogene, respectively, despite the high sequence identity of their substrate binding domains (SBDs).
|
27776223 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of SIAH1 in breast cancer is still ambiguous; both tumorigenic and tumor suppressive functions have been reported.
|
26654769 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
On the contrary, silencing of miR-107 increased SIAH1 expression and inhibited the tumor growth of MDA-MB-231 cells, a kind of triple-negative breast cancer (TNBC) cells, in vitro and in vivo.
|
25851994 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The observed effects were due to the inhibitory action of miR-135a on its direct target seven in absentia homolog 1 (SIAH1) leading to upregulation of β-catenin/T cell factor signaling. miR-135a force-expression enhanced the growth of HeLa- and NC104-E6/E7-derived tumor in vivo.
|
24503442 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that development of drugs augmenting Siah1 and Siah1L activity could be a novel approach in improving tumor cell kill.
|
20682032 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that c-MYB is targeted by miR-155 and miR-424, that the tumor suppressor SIAH1 is targeted by miR-424, and that c-SKI is potentially regulated by miR-155.
|
21062812 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage.
|
23228635 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These observations suggest SIAH1 as a candidate tumor suppressor gene that may be inactivated during tumorigenesis.
|
10956387 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages.
|
12557228 |
2003 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells.
|
29217406 |
2018 |
|
Oropharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To determine whether Siah-1 is important for the proteasomal degradation of beta-catenin in HPV16-positive oropharyngeal cancer cells, we introduced a Siah-1 expression vector into 147T and 090 cells and found substantial reduction of endogenous beta-catenin in these cells.
|
20215420 |
2010 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
LHGDN |
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.
|
18089810 |
2007 |