leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
B cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) is a crucial regulator of CSC self-renewal, malignant transformation and EMT, and a previous study from our group showed that Bmi-1 is upregulated in pancreatic cancer progression and participates in EMT.
|
30453285 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell-specific moloney leukemia virus insertion site 1 (Bmi-1) plays important roles in various cancers, but its regulation through microRNAs (miRNAs) and its functions in hepatocellular carcinoma (HCC) remains unclear.
|
29906128 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, quantitative real-time polymerase chain reaction was used to study changes in the expression of tumor suppressor proteins 53 and 21 ( P53 and P21), cluster of differentiation 44 ( CD44), and B cell-specific Moloney murine leukemia virus integration site 1 ( BMI-1) upon treatments.
|
27207438 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bmi-1, the B cell-specific moloney murine leukemia virus insertion site 1, is a member of the Polycomb-group (PcG) family and acts as an oncogene in various tumors; however, its expression related to the prognosis of pediatric patients with acute lymphoblastic leukemia (ALL) has not been well studied.
|
28122538 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) is required for the self-renewal and maintenance of AML stem cells.
|
28211885 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
BMI1 inhibition suppressed proliferation of leukemia cells through NOTCH signaling which functions downstream of BMI1, suggesting that BMI1 inhibitors can be candidate targeted drugs against leukemia.
|
29061784 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, we found that Shh-Gli1 signaling regulates the expression of one stem cell marker, BMI1 (B cell-specific Moloney murine leukemia virus), in glioma.
|
27662839 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IG-BMI1 translocations were not associated with any particular molecular subtype of CLL and the leukemias were negative for common mutations of NOTCH1 and TP53, known to increase a risk of progression and transformation in CLL.
|
23873701 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, unlike in vivo expanded CML B-lymphoid progenitors, hematopoietic stem cells, or multipotent progenitors, coexpressing BCR-ABL and Bmi1 did not initiate or propagate leukemia in a limiting dilution assay.
|
22101899 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The oncoprotein B-cell-specific Moloney murine leukemia virus integration site 1 protein (Bmi-1) has been linked to the development and progression of glioma; however, the biological role of Bmi-1 in the invasion of glioma remains unclear.
|
22967049 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that BMI1 collaborates with BCR-ABL in inducing a fatal leukemia in nonobese diabetic/severe combined immunodeficiency mice transplanted with transduced human CD34(+) cells within 4-5 months.
|
20724541 |
2010 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also observed that HOXA9 levels were significantly inversely correlated with survival and that BMI-1 was overexpressed in cases with 11q23 rearrangements, suggesting that p19(ARF) suppression may be involved in MLL-associated leukemia.
|
18668134 |
2008 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examine the role of Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) as a regulator of human epidermal keratinocyte survival.
|
17625597 |
2008 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It has been demonstrated that over-expression of Bmi-1 occurs in a variety of cancers, including several types of leukemia.
|
17454639 |
2007 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reducing SALL4 expression by siRNA in the HL-60 leukemia cell line also results in significant down-regulation of Bmi-1.
|
17557835 |
2007 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
One of the best candidate genes involved in conferring self-renewal capacity is Bmi-1, which has been proven to be essential for the maintenance of both normal adult hematopoietic and leukemia stem cells, as well as adult neural stem cells.
|
17395774 |
2007 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we demonstrate that activation of the BMI1 oncogene-associated PcG pathway plays an essential role in metastatic prostate cancer, thus mechanistically linking the pathogenesis of leukemia, self-renewal of stem cells, and prostate cancer metastasis.
|
16963837 |
2006 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of the polycomb group gene Bmi1 promotes cell proliferation and induces leukaemia through repression of Cdkn2a (also known as ink4a/Arf) tumour suppressors.
|
15029199 |
2004 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) on metaphase chromosome spreads located the human BMI-1 gene to the short arm of chromosome 10 (10p13), a region known to be involved in translocations in various leukemias.
|
8268912 |
1993 |