|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study.
|
29503163 |
2018 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that partial loss of the Slc1a1 gene in mice causes haploinsufficiency associated with behavioral, histological and biochemical changes that reflect an altered redox state and may promote the expression of behavioral features and inflammatory states consistent with those observed in schizophrenia.
|
28886095 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Other plausible candidates include non-recurrent deletions at the glutamate transporter gene SLC1A1, a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1.
|
24163246 |
2014 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family.
|
23341099 |
2013 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggest that SLC1A1 is unlikely to be a major susceptibility gene for schizophrenia in Han Chinese.
|
23931931 |
2013 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings suggest the involvement of SLC1A1 in the pathogenesis of schizophrenia.
|
22095641 |
2012 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP treatment.
|
21990008 |
2011 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We did not detect N-linked glycosylation of EAAT3 in either schizophrenia or the comparison subjects in these regions.
|
19716271 |
2010 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To determine whether polymorphisms in SLC1A1 are associated with AAP-induced OC symptoms in patients with schizophrenia.
|
19884611 |
2009 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Coexpression of the schizophrenia-associated mutant (N251S)PIP5K2A significantly decreased I(glu) in oocytes expressing EAAT3 with or without additional expression of wild type PIP5K2A.
|
19644675 |
2009 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We concluded that at least one susceptibility locus for schizophrenia may be located within or nearby SLC1A6, whereas SLC1A1 and SLC1A3 are unlikely to be major susceptibility genes for schizophrenia in the Japanese population.
|
17221839 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
We concluded that at least one susceptibility locus for schizophrenia may be located within or nearby SLC1A6, whereas SLC1A1 and SLC1A3 are unlikely to be major susceptibility genes for schizophrenia in the Japanese population.
|
17221839 |
2007 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using quantitative reverse transcription-polymerase chain reaction, we established that the expression of the EAAT1, EAAT2a, EAAT2b, and EAAT3 transcripts was not different in the dorsolateral prefrontal and primary visual cortices of persons with schizophrenia relative to matched controls.
|
16297566 |
2006 |
|
Schizophrenia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We also detected decreased EAAT3 transcript expression in schizophrenia and decreased EAAT4 transcript expression in major depressive disorder.
|
11850151 |
2002 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Higher expressions of transcripts encoding EAAT1 and EAAT2, but not EAAT3, were detected in the thalamus of subjects with schizophrenia.
|
11532723 |
2001 |
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|