|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Western blot results revealed that the expression of Akt, PI3K, IRS-1, and GLUT4 were upregulated in skeletal muscle of type 2 diabetes (T2D) rats and in L6 myotubes by Ph.
|
28223777 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human.
|
28529958 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
GLUT4 content and its activation as well as SLC2A4 gene expression level are decreased in patients with type 2 diabetes.
|
26529385 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
Increased STX8 expression in VAT appears to be associated with the presence of T2D in obese patients through a mechanism that may involve GLUT4.
|
25523146 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our findings manifest that EK100 may have therapeutic potential in treating type 2 diabetes associated with hyperlipidemia in HFD-fed mice by regulation of GLUT4, PEPCK, G6 Pase, SREBP1c, SREBP2, apo A-I, and AMPK phosphorylation.
|
25693659 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
GLUT4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy.
|
25596527 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
H(2) significantly increased skeletal muscle membrane Glut4 expression and markedly improved glycemic control in STZ-induced type 1 diabetic mice after chronic intraperitoneal (i.p.) and oral (p.o.) administration.However, long-term p.o. administration of H(2) had least effect on the obese and non-insulin-dependent type 2 diabetes mouse models.
|
23326534 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Our findings showed that adipose GLUT4 gene expression changes were more related to insulin resistance and type 2 diabetes rather than to obesity.
|
21604201 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Recent studies in south Indian populations revealed that haplotypes of the GLUT4 gene associated with type 2 diabetes.
|
22673408 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
The aim of this study was the estimation of insulin resistance indicators and the quantitative expression of GLUT-1, GLUT-3 and GLUT-4 on peripheral blood lymphocytes in prediabetic subjects and persons with a positive family history of type 2 diabetes during 24 months of observation.
|
22744628 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
CTD_human |
All our results have thus highlighted the potential of Rut as both a valuable lead compound for anti-T2DM drug discovery and a promising chemical probe for GLUT4 associated pathways exploration.
|
22384078 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
All our results have thus highlighted the potential of Rut as both a valuable lead compound for anti-T2DM drug discovery and a promising chemical probe for GLUT4 associated pathways exploration.
|
22384078 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
Insulin-stimulated glucose uptake by the glucose transporter GLUT4 plays a central role in whole-body glucose homeostasis, dysregulation of which leads to type 2 diabetes.
|
22473005 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.
|
22349765 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.
|
22340256 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
Moreover, GLUT4, a member of the solute carrier family 2, may play a role in the patient's type 2 diabetes.
|
22365944 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
The GLUT4 gene was sequenced in 25 normal glucose tolerance (NGT) and 25 T2DM subjects, and the variants found were then genotyped by polymerase chain reaction-restriction fragment length polymorphism in a pilot study population of 552 NGT and 643 T2DM subjects, randomly selected from the Chennai Urban Rural Epidemiology Study.
|
21668369 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
GLUT4 protein levels may therefore play a role in the pathology behind type 2 diabetes mellitus among subgroups of patients, and this may explain the heterogeneous response to insulin treatment.
|
22114711 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis revealed that two common haplotypes H1 (111, P = 0.001, OR 1.23[1.08-1.40]) and H2 (222, P = 0.002 OR 0.73[0.59-0.89]) in STRA6, H6 (2121, P = 0.006, OR 1.69[1.51-2.48]) in RBP4 and H4 (2121, P = 0.01 OR 1.41[1.07-1.85]) in GLUT4 were associated with type 2 diabetes.
|
20625434 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The goal of the present study is to develop a cell-based assay for identifying negative regulators of GLUT4 translocation as potential targets for the treatment of Type 2 diabetes.
|
19035854 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Adaptation to states of enhanced metabolic demand is associated with increased glucose metabolism and GLUT4 gene expression, whereas states of insulin resistance such as type 2 diabetes mellitus (DM2), obesity, and aging are associated with impaired regulation of GLUT4 gene expression and function.
|
18492767 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Type 2 diabetes mellitus and obesity are associated with impaired regulation of GLUT4 gene expression and elevated levels of free fatty acids and proinflammatory factors.
|
17317207 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
Gene expressions of insulin receptor (INSR), vitamin D receptor, insulin degrading enzyme, Akt, insulin receptor substrate-1 (IRS-1), IRS-2, glucose transporter 4 (GLUT4), and enzymes of the glycolytic pathway were decreased at least 50% in T2DM than in controls.
|
18267303 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
CTD_human |
Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war.
|
17107852 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.800 |
Biomarker
|
disease |
BEFREE |
In conclusion, the uncoupling of insulin action on Akt/AS160 signaling and glucose transport implicates defective GLUT4 trafficking as an early event in the pathogenesis of type 2 diabetes.
|
16644684 |
2006 |