BMP4, bone morphogenetic protein 4, 652

N. diseases: 423; N. variants: 21
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. 29259041 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE The present study investigated whether PDGF mediates BMP4-induced endothelial dysfunction in diabetes mellitus. 26769046 2016
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE Bone morphogenic protein 4 (BMP4) is involved in the development of endothelial dysfunction in hypertension. 24202302 2014
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 AlteredExpression phenotype BEFREE Bone morphogenic protein 4 (BMP4) expression is increased in endothelium in atherosclerosis-prone regions and is known to induce endothelial inflammation, endothelial dysfunction, and hypertension. 23559633 2013
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE BMP4 increased p38 mitogen-activated protein kinase (MAPK) activity through a ROS-sensitive mechanism and p38 MAPK inhibitor prevented BMP4-induced endothelial dysfunction. 20724703 2010
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.060 Biomarker phenotype BEFREE These results suggest that BMP4 infusion induces hypertension in mice in a vascular NADPH oxidase-dependent manner and the subsequent endothelial dysfunction. 16769910 2006