|
Primary biliary cirrhosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The decreased expression of AE2 was correlated with dysregulated autophagy, abnormal expression of PDC-E2, and cellular senescence in bile duct lesions in PBC.
|
29540861 |
2018 |
|
Primary biliary cirrhosis
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Of note, two SLC4A2 variants appear to influence AMA status among PBC patients.
|
19491853 |
2009 |
|
Primary biliary cirrhosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
They also demonstrate that allelic variations in TNFalpha and SLC4A2/AE2 have a significant impact on the evolutive profile of PBC under UDCA therapy.
|
18930330 |
2008 |
|
Primary biliary cirrhosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
In this review, we discuss the experimental evidence for the emerging role of the miR-506-AE2-sAC axis in PBC pathogenesis.
|
28962898 |
2018 |
|
Primary biliary cirrhosis
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with PBC development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients.
|
21594562 |
2011 |
|
Primary biliary cirrhosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical studies indicated that the expression of the AE2 protein is decreased in the bile ducts and hepatocytes in PBC livers.
|
21691115 |
2011 |
|
Primary biliary cirrhosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
In addition, we observed that though cAMP increased AE2 activity in cholangiocytes from both normal and non-PBC livers, this effect was absent in PBC cholangiocytes.
|
12029638 |
2002 |
|
Primary biliary cirrhosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Here, we tested the potential role of microRNA 506 (miR-506) - predicted as candidate to target AE2 mRNA - for the decreased expression of AE2 in PBC.
|
22383162 |
2012 |
|
Primary biliary cirrhosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
To directly address the role of AE2 in preventing PBC pathogenesis, we took advantage of our ability to isolate human BEC and autologous splenic mononuclear cells (SMC).
|
27592379 |
2016 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms.
|
29191842 |
2018 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical staining showed that AE2 was primarily located in the cell membranes or cytoplasm of carcinoma cells, and its expression pattern at the invasive front of the tumor was related to the pT category.
|
29899837 |
2018 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration.
|
31546841 |
2019 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gastrin inhibited proliferation of colon cancer cells by suppressing expression of EGR1 and AE2 and by blocking ERK phosphorylation.
|
22228178 |
2012 |
|
Cholangitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of AE2 was significantly decreased in cholangitis in PBC, compared to control livers (p < 0.05).
|
29540861 |
2018 |
|
Cholestasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this work, we ascertained whether AE2 expression and/or activity is reduced in hepatocytes from rats with common bile duct ligation (BDL), as part of the adaptive response to cholestasis.
|
30789925 |
2019 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The progression rate of liver disease under ursodeoxycholic acid (UDCA) therapy was significantly linked to SNPs of TNFalpha and SLC4A2/anion exchanger 2 (AE2) genes.
|
18930330 |
2008 |
|
Osteopetrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that a deletion mutation within bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle.
|
20507629 |
2010 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
Finally, a macrocyclic AE2 targeting peptide exhibiting increased stability <i>in vivo</i> was effective in mice xenografted with B-cell lymphoma.
|
29191842 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The aims of the present study were to investigate the role of anion exchanger 2 (AE2) in the regulation of tumor progression-related genes and the prognostic value of its expression in esophageal squamous cell carcinoma (ESCC).
|
29899837 |
2018 |
|
Adenocarcinoma, Tubular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis of 24 patients with colon cancer in early stage or 33 patients with tubular adenocarcinoma demonstrated that expression of AE2 is correlated with poor prognosis.
|
22228178 |
2012 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that bile acid uptake and toxicity in human immortalized cholangiocytes and cholangiocarcinoma cell lines in vitro were pH and AE2 dependent, with the highest rates at low pH and when AE2 expression was defective.
|
21932391 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of the present study suggest that reductions in AE2 in ESCC enhance cellular movement by activating MMP signaling pathways and are related to a poor prognosis in patients with ESCC.
|
29899837 |
2018 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gastrin inhibited proliferation of colon cancer cells by suppressing expression of EGR1 and AE2 and by blocking ERK phosphorylation.
|
22228178 |
2012 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration.
|
31546841 |
2019 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our previous findings showed that AE2 gene was highly expressed in a poorly differentiated HCC cell line, HA22T/VGH.
|
19224338 |
2009 |