Primary biliary cirrhosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
In addition, we observed that though cAMP increased AE2 activity in cholangiocytes from both normal and non-PBC livers, this effect was absent in PBC cholangiocytes.
|
12029638 |
2002 |
Alkalosis
|
0.200 |
Biomarker
|
phenotype |
RGD |
Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis.
|
17367404 |
2007 |
Primary biliary cirrhosis
|
0.390 |
Biomarker
|
disease |
CTD_human |
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
|
18188457 |
2008 |
Biliary cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
|
18188457 |
2008 |
Secondary Biliary Cholangitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
|
18188457 |
2008 |
Biliary Cirrhosis, Primary, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells.
|
18188457 |
2008 |
Achlorhydria
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Expression of anion exchanger 2 in human gastric cancer.
|
18438347 |
2008 |
Stomach Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
We have studied AE2 expression in normal human gastric tissues (n =16) and in gastric tumors (n = 33) using immunohistochemistry and immunofluorescent labeling.
|
18438347 |
2008 |
Primary biliary cirrhosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
They also demonstrate that allelic variations in TNFalpha and SLC4A2/AE2 have a significant impact on the evolutive profile of PBC under UDCA therapy.
|
18930330 |
2008 |
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The progression rate of liver disease under ursodeoxycholic acid (UDCA) therapy was significantly linked to SNPs of TNFalpha and SLC4A2/anion exchanger 2 (AE2) genes.
|
18930330 |
2008 |
Autosomal Recessive Polycystic Kidney Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Autosomal Recessive Polycystic Kidney Disease
|
0.500 |
Biomarker
|
disease |
RGD |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Choledochal Cyst
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Choledochal Cyst, Type I
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Choledochal Cyst, Type II
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Choledochal Cyst, Type III
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Choledochal Cyst, Type IV
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Choledochal Cyst, Type V
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease.
|
18988797 |
2008 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our previous findings showed that AE2 gene was highly expressed in a poorly differentiated HCC cell line, HA22T/VGH.
|
19224338 |
2009 |
Primary biliary cirrhosis
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Of note, two SLC4A2 variants appear to influence AMA status among PBC patients.
|
19491853 |
2009 |
Osteopetrosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that a deletion mutation within bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle.
|
20507629 |
2010 |
Primary biliary cirrhosis
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with PBC development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients.
|
21594562 |
2011 |
Primary biliary cirrhosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical studies indicated that the expression of the AE2 protein is decreased in the bile ducts and hepatocytes in PBC livers.
|
21691115 |
2011 |
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that bile acid uptake and toxicity in human immortalized cholangiocytes and cholangiocarcinoma cell lines in vitro were pH and AE2 dependent, with the highest rates at low pH and when AE2 expression was defective.
|
21932391 |
2012 |
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gastrin inhibited proliferation of colon cancer cells by suppressing expression of EGR1 and AE2 and by blocking ERK phosphorylation.
|
22228178 |
2012 |