SLC5A2, solute carrier family 5 member 2, 6524

N. diseases: 214; N. variants: 20
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.020 Biomarker phenotype BEFREE The data point to novel antioxidant therapeutic strategies including use of an SGLT2 inhibitor and sulforaphane to mitigate hyperglycaemia-induced endothelial dysfunction. 29908295 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.020 Biomarker phenotype BEFREE Following 4-week repeated administration to diabetic mice, all SGLT2 inhibitors showed significant improvement in diabetes-related diseases and complications, including obesity; abnormal lipid metabolism; steatohepatitis; inflammation; endothelial dysfunction; and nephropathy. 28506912 2017