SLC5A2, solute carrier family 5 member 2, 6524

N. diseases: 214; N. variants: 20
Disease: Cardiac fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis 		0.020 Biomarker disease BEFREE Since either MMPs or SGLT2 have important roles in cardiac-fibrosis under hyperglycemia, we aimed to examine the role of SGLT2 inhibitor dapagliflozin (DAP) on cardiac Zn<sup>2+</sup>-transporters responsible for [Zn<sup>2+</sup>]<sub>i</sub>-regulation, comparison to insulin (INS), together with MMP levels and systemic oxidative stress status in MetS-rats. 30444646 2019
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis 		0.020 Biomarker disease BEFREE The effects of SGLT2 inhibitors on cardiac fibrosis were nullified by adding S3I-201. 28132924 2017