Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE Manipulation of WNK2 expression affects miR-370-mediated cell proliferation and tumor growth. 31009242 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE We also explored the functional effect and mechanism of WNK2 on tumor growth and metastasis. 31349001 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE WNK2, which is exclusively enriched in neurons, is well known as an anti-proliferative tumor suppressor. 27131446 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter methylation in gliomas. 25596741 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 PosttranslationalModification group BEFREE WNK2 hypermethylation was higher in tumor than in surrounding inflamed tissues and was observed in PanIN lesions as well as in a PDAC mouse model. 23912455 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE Together, these results validate the WNK2 gene as a recurrent target for epigenetic silencing in glia-derived brain tumours and provide first mechanistic evidence for a tumour-suppressing role of WNK2 that is related to Rac1 signalling and tumour cell invasion and proliferation. 23035050 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 Biomarker group BEFREE Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific. 19001526 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 GeneticVariation group BEFREE The WNK2 silencing by epigenetic mechanisms was significantly associated (P < 0.01) with a known genetic signature of chemosensitive oligodendroglial tumors, 1p and 19q deletion, in two small but independent tumor sets. 17578925 2007