|
Acute Promyelocytic Leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Some additional data, such as expression of myeloperoxidase, monocyte-specific esterase and annexin VIII, together with the cytogenetic and molecular biological information, suggest that NB-4 is the only genuine promyelocytic leukemia cell line, whereas HL-60 may represent a discrete stage of differentiation between the late myeloblasts and the promyelocyte; PL-21 has distinct features associated with monocytic cells.
|
7500643 |
1995 |
|
Acute Promyelocytic Leukemia
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
Expression of the annexin VIII gene in acute promyelocytic leukemia.
|
8069182 |
1994 |
|
Acute Promyelocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Analysis of the expression of annexin VIII protein in NB4 cells and in APL samples showed a consistent expression of a predominant 36-kD protein and a weak 72-kD protein.
|
8018923 |
1994 |
|
Acute Promyelocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Annexin VIII mRNA was found to be specifically expressed in acute promyelocytic leukemia (APL) cells; it was not found in other types of acute myeloid leukemia (AML) nor in lymphoid malignancies.
|
8231235 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Annexin VIII is highly expressed in the APL cell line, NB4.
|
1313714 |
1992 |
|
Squamous cell carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Both KRT19 and ANXA8 mRNA may be useful markers for detecting lymph node metastases in OSCC patients.
|
26700817 |
2016 |
|
Squamous cell carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The SCC-like expression signature comprised ANXA8, CK5, IFI16, and nectin-1; and the AC-like signature comprised EpCAM, and TMEM98.
|
20855955 |
2010 |
|
Squamous cell carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, genes involved in epidermal differentiation complex such as S100A9 and ANXA8 were upregulated in SC.
|
16450401 |
2006 |
|
Noninfiltrating Intraductal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These miRNAs are candidate components of the RA-RARA-ANXA8 mechanism, and their deregulation might induce DCIS initiation.
|
30678048 |
2019 |
|
Noninfiltrating Intraductal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Second, we show that ANXA8 expression is significantly higher in DCIS tissue samples versus normal breast tissue and atypical ductal hyperplasia (ADH).
|
27422542 |
2016 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Apparently, ANXA8 expression is significantly more upregulated in ER-negative versus ER-positive cases, and significantly correlates with tumor stage, grade and positive lymph node.
|
27422542 |
2016 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In our tissue microarray, A-A8 expression increased 5.9-fold (r = 0.31; P = 0.019) from low- to high-grade tumors, correlating with tumor grade (r = 0.23; P = 0.027).
|
25268673 |
2015 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Clinicopathological features and associations between increased A-A8 expression (determined by immunohistochemistry) and histologic grade were studied in a tissue microarray of 90 patients with resected stage I/II pancreatic cancer.
|
25268673 |
2015 |
|
Malignant neoplasm of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Clinicopathological features and associations between increased A-A8 expression (determined by immunohistochemistry) and histologic grade were studied in a tissue microarray of 90 patients with resected stage I/II pancreatic cancer.
|
25268673 |
2015 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Involvement of annexin A8 in the properties of pancreatic cancer.
|
23001853 |
2014 |
|
Malignant neoplasm of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Involvement of annexin A8 in the properties of pancreatic cancer.
|
23001853 |
2014 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Most deregulated genes have been reported as potentially implicated in cancer and severals, as ANXA8 and FBN1, are highlighted by both, mRNA and miRNA analyses.
|
23593401 |
2013 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Annexin VIII mRNA was found to be specifically expressed in acute promyelocytic leukemia (APL) cells; it was not found in other types of acute myeloid leukemia (AML) nor in lymphoid malignancies.
|
8231235 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Annexin VIII mRNA was found to be specifically expressed in acute promyelocytic leukemia (APL) cells; it was not found in other types of acute myeloid leukemia (AML) nor in lymphoid malignancies.
|
8231235 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Expression of the annexin VIII gene in all other leukemias, including acute myelogenous leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia, and acute lymphoblastic leukemia, was undetectable, except in one patient with acute myelogenous leukemia in which a very low level of expression was detected.
|
1313714 |
1992 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, results suggested that ANXA8 was most closely associated with ovarian cancer tumorigenesis and progression.
|
31474227 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins.
|
31474227 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins.
|
31474227 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins.
|
31474227 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, with previous experimental evidences, the present review discussed the role of FoxOs in association with metastasis related molecules including cannabinoid receptor 1 (CNR1), Cdc25A/Cdk2, Src, serum and glucocorticoid inducible kinases (SGKs), CXCR4, E-cadherin, annexin A8 (ANXA8), Zinc finger E-box-binding homeobox 2 (ZEB2), human epidermal growth factor receptor 2 (HER2) and mRNAs such as miR-182, miR-135b, miR-499-5p, miR-1274a, miR-150, miR-34b/c and miR-622, subsequently analyzed the molecular mechanism of some natural compounds targeting FoxOs and finally suggested future research directions in cancer progression and metastasis.
|
28774834 |
2018 |