|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset.
|
30554102 |
2019 |
|
Anorexia Nervosa
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa.
|
31804778 |
2019 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparisons of network properties were made between the AN and HC groups and, within each group, between 5-HTTLPR carriers of low-functioning alleles and carriers of the long-long genotype.
|
31680805 |
2019 |
|
Anorexia Nervosa
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Increased rsFC in the salience network mediated the link between SLC6A4 methylation and eating disorder symptoms in patients with anorexia nervosa.
|
31823595 |
2019 |
|
Anorexia Nervosa
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that 5-HTTLPR is able to confer susceptibility to AN in Han Chinese.
|
25785698 |
2015 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The S-allele of the 5-HTTLPR genotype increases the risk susceptibility for both depressive comorbidity (OR = 4.23; 95% CI, 1.45-12.37) and diagnostic crossover during the follow-up period in AN patients (OR = 5.04; 95% CI, 1.69-14.98).
|
22488946 |
2012 |
|
Anorexia Nervosa
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated functional characteristics of the platelet 5-HT transporter and platelet 5-HT content in AN patients at various stages of their illness in comparison to healthy control woman (HCW) controlling for the 5-HTTLPR deletion/insertion polymorphism and other confounding variables.
|
19957188 |
2010 |
|
Anorexia Nervosa
|
0.100 |
Biomarker
|
disease |
LHGDN |
The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study.
|
16397402 |
2006 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the -1438 A/G polymorphism in the 5-HT2A receptor gene and serotonin transporter linked-polymorphic region (5-HTTLPR) in 132 adolescent subjects with AN and in 93 healthy controls.
|
16397402 |
2006 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A SERT gene genotype with no apparent individual effect on risk and known to be associated with anxiety is preferentially transmitted to children with AN (chi2 trend=9.457, 1 df, P=0.0021) and AN-R alone (chi2 trend=7.477, 1 df, P=0.0063) when the 'more active' MAOA gene variant is also transmitted.
|
15523490 |
2005 |
|
Anorexia Nervosa
|
0.100 |
Biomarker
|
disease |
LHGDN |
Epistatic interaction between the monoamine oxidase A and serotonin transporter genes in anorexia nervosa.
|
15523490 |
2005 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The 5-HTTLPR S allele might play some role in the development of AN with persistent disease.
|
15211642 |
2004 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the SLC6A4*S allele has been assessed in four independent samples of patients with anorexia nervosa, but gave discrepant results.
|
14987118 |
2004 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa.
|
15211642 |
2004 |
|
Anorexia Nervosa
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although 5-HTTLPR modulates serotonin reuptake by the serotonin transporter, our analyses provide no evidence that susceptibility to AN is modified by 5-HTTLPR alone, nor in concert with as yet undetermined functional effects of the NETpPR polymorphism.
|
12784104 |
2003 |
|
Anorexia Nervosa
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that there is no association between 5-HTTLPR genotype and susceptibility to AN, in our population.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:53-55, 2000.
|
10686552 |
2000 |