|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Understanding the molecular regulation of placental SERT and 5-HT receptors using selective pharmacological agonists or antagonists may identify the therapeutic potential of serotonin pathway to improve long-term health outcomes of mothers and her infants exposed to GDM and obesity.
|
30738809 |
2020 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, negative correlative data showed that CpG10-associated 5-HTT availability determines levels of reward sensitivity in obesity.
|
28675387 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aims were to determine whether (a) the SLC6A4-promoter variant (5-HTTLPR) relates to disinhibition; (b) this association could affect total weight-loss during a behavioral/dietary treatment for obesity.
|
28766852 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found some evidences for the association of SLC6A4 and MAOA genes with measures of obesity.
|
26698543 |
2016 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant statistical association of 5-HTTLPR polymorphism with type 2 diabetes and obesity in Pakistani population shows that 5-HTTLPR polymorphism is not a major factor in determining type 2 diabetes and obesity in Pakistan.
|
25680681 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BMI values for genotype of obese and morbidly obese (BMI > 40) individuals were analyzed by Kruskal-Wallis and not found statistically significant differences between BMI values for the most frequent genotypes of 5-HTT, DAT1 and DRD4 genes.
|
25687785 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In obese patients S allele of 5-HTTLPR was associated with development of depressive temperament while L allele corresponded with greater obesity and prevalence of depression.
|
26093833 |
2015 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Differences in 5-HT vulnerability are genetically determined, including a short (S) allele polymorphism in the serotonin transporter gene (5-HTTLPR) that is associated with serotonin dysfunction and is therefore believed to increase the risk for obesity.
|
22955839 |
2012 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to investigate the possible association of 5-HTTLPR polymorphism with type 2 diabetes mellitus and obesity.
|
19891962 |
2010 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Associations between the 5-HTTLPR and BMI and obesity (BMI > or = 25 kg/m2) were examined in all subjects.
|
19411808 |
2009 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study addressed the hypothesis that variation in genes associated with dopamine function (SLC6A3, DRD2, DRD4), serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories (obese and overweight + obese) in young adulthood and of changes in BMI as adolescents transition into young adulthood.
|
18239643 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our findings indicate that 5-HTTLPR polymorphism may be linked with BMI and also with obesity and/or overweight in adult male population, reinforcing the role of the serotonin transporter as a risk factor for the obesity phenotype and suggesting potential new avenues for its pharmacological treatment.
|
18239665 |
2008 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the incidence of the following polymorphisms in the following genes in 262 obese (BMI > or = 30) and 138 control (BMI < or = 25) subjects: leptin receptor (LEPR)-Gln223Arg, B3-adrenergic receptor (B3-AR)-Trp64Arg, serotonin transporter (5-HTT)--a 44-base pair insertion/deletion functional polymorphism in the 5-HTTLPR and insulin receptor substrate-1 (IRS-1)-Gly972Arg.
|
17124363 |
2007 |