|
Impulsive character (finding)
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Seven studies were identified by the systematic review, with complete data sets of five community (n = 1750, 64.5% female) and two clinical (n = 426, 100% female) samples combined to perform four secondary-data analyses: 5-HTTLPR x Traumatic Life Events to predict ED status (n = 909), 5-HTTLPR x Sexual and Physical Abuse to predict bulimic symptoms (n = 1097), 5-HTTLPR x Depression to predict bulimic symptoms (n = 1256), and 5-HTTLPR x Impulsiveness to predict disordered eating (n = 1149).
|
27701012 |
2017 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Here we report an association study of both dopaminergic (COMT rs4680, DRD4 48 bp VNTR, DRD2/ANKK1 rs1800497) and serotonergic (HTR1A rs6925, HTR1B rs13212041, SLC6A4 5-HTTLPR) gene polymorphisms and trait impulsivity assessed with the Barratt Impulsiveness Scale (BIS-11) in a sample of 687 Caucasian young adults.
|
22259185 |
2012 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In our main analyses with Barratt Impulsiveness Scale (BIS-11) total score, there were significant (i.e. p<.01 and False Discovery Rate <.10) interactions between (1) gender and TPH2 (rs1386483) genotype; (2) gender and HTR2A (rs6313) genotype; and epistatic interactions among (3) 5-HTTLPR and MAOA uVNTR; (4) 5-HTTLPR and rs6313 and (5) HTR1B (rs6296) and rs6313 genotypes.
|
22735397 |
2012 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Furthermore, the effects of the 5-HTTLPR genotype on impulsiveness in this Japanese sample were particularly accounted for by perceived rejection from the mother or father.
|
23112823 |
2012 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently and additively, associated with elevated impulsive response style in Caucasian men.
|
20188795 |
2010 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The association between different impulsive-disinhibited personality traits with 5-HTTLPR and 5-HTTVNTR genetic polymorphisms was examined in an imprisoned male sample.
|
19121834 |
2009 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The effect of 5-HTTLPR S allele on impulsive performance remained significant after controlling for general cognitive abilities.
|
17628790 |
2007 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our data suggest that a decreased expression of the gene encoding the 5-HTT transporter, due to "S" promoter polymorphism, may be associated with an increased risk for substance use disorders, particularly in the subjects with more consistent aggressiveness and impulsiveness.
|
15048645 |
2004 |
|
Impulsive character (finding)
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
When controlled for the impact of several psychopathologies related to violent behavior, this association was observed in individuals with a history of childhood attention deficit/hyperactivity disorder (ADHD)-related symptoms, but not presenting with personality disorder or increased impulsiveness.In conclusion, the results (i). suggest an association between serotonergic dysfunction and violent behavior, (ii). provide evidence for an-at least partial-genetic regulation of violent behavior in a subgroup of male offenders, and (iii). suggest a significant role for 5-HT transporter functionality for violent behavior.
|
15211560 |
2004 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The distribution of allelic frequency was determined and also investigated the relationship of the 5-HTTLPR polymorphism to a impulsive trait as measured by the Barratt Impulsiveness Scale, 11th version (BIS-11).
|
12898578 |
2003 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The findings do not seem to support an association between these polymorphisms in the 5HTT gene and impulsive-aggressive traits among cocaine-dependent African-American individuals.
|
12057823 |
2002 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Toward unraveling a possible role of the 5-HTTLPR polymorphism in childhood disruptive behaviors, we examined this gene in attention deficit hyperactivity disorder (ADHD), a heterogeneous childhood disorder in which three phenotypes are recognized by DSM IV criteria: inattentive (type I), hyperactive-impulsive (type II), and combined type (type III).
|
11425009 |
2001 |
|
Impulsive character (finding)
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The results suggest that the 5-HTT 'S' promoter polymorphism is associated with an increased risk for early onset alcoholism associated with antisocial personality disorder and impulsive, habitually violent behavior.
|
10483057 |
1999 |