|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Ncf1-deficient mice expressed pronounced interferon signature, which could be normalized by conditional expression of Ncf1 and was also present in the Ncf1-mutated mouse during arthritis.
|
28467721 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ncf1 mutant mice exhibited more severe G6PI peptide-induced arthritis, which was accompanied by the increased GILT expression in macrophages and enhanced Ag-specific T cell responses.
|
29127146 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Through establishing an arthritis model by injecting arthritogenic serum into wild-type and NADPH oxidase 2 (NOX2)-deficient mice, we found that arthritis had a neutrophilic infiltrate and was more severe in Ncf1(-/-) mice, a mouse strain lacking the expression of the NCF1/p47(phox) component of NOX2.
|
25867281 |
2015 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We generated germ-free ROS deficient Ncf1 mutant mice that when reared in specific pathogen-free condition, are highly susceptible to collagen-induced arthritis compared with wild-type mice.
|
25689796 |
2015 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ncf1*/* mice developed arthritis also on immunization with the mouse G6PI325-339 peptide and in the absence of C5.
|
23911657 |
2013 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In rodent models, a single-nucleotide polymorphism (SNP) in Ncf1 has been shown to be a major locus regulating severity of arthritis.
|
21728841 |
2012 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When this Ncf1 allele was backcrossed to the arthritis susceptible DA strain, both granulocyte ROS production and arthritis resistance were restored.
|
21275845 |
2011 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transfer of T cells from vaccinated mice with functional Ncf1 protein resulted in strong suppression of clinical signs of arthritis in B10.Q mice, whereas the Ncf1 mutated mice as recipients had a weaker suppressive effect, suggesting that ROS modified the secondary rather than the primary immune response.
|
20686129 |
2010 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previously, we showed that in p47(phox)-mutated mice, reconstitution of macrophages (Mph) with ROS-producing capacity was sufficient to protect the mice from arthritis.
|
20861446 |
2010 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Maximum linkage to pristane-induced arthritis occurred less than 130 kb from the known genetic arthritis determinants Ncf1 and APLEC, demonstrating remarkable mapping precision.
|
19066175 |
2009 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prevailing hypothesis that ROS promote inflammation was recently challenged when polymorphisms in Neutrophil cytosolic factor 1(Ncf1), that decrease oxidative burst, were shown to increase disease severity in mouse and rat arthritis models.
|
19052348 |
2008 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the introduction of a mutation in the Ncf1 gene, which is responsible for the reduced oxidative burst phenotype, into the COMPIA-resistant B10.Q mouse strain rendered them highly susceptible to arthritis.
|
18576344 |
2008 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
By studying animal models, reduced capacity of the NADPH-oxidase (NOX) complex, caused by a single nucleotide polymorphism (SNP) in one of its components (the NCF1 gene), has been found to increase severity of arthritis.
|
17897462 |
2007 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The use of linkage analysis and positional cloning of genes in animal models for RA resulted in the identification of one of the genes regulating severity of arthritis in rats and mice, the Ncf1 gene.
|
16724810 |
2006 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results show that Ncf1, a gene important for oxidative burst, regulates the susceptibility and severity of both arthritis and encephalomyelitis and modulates, directly or indirectly, the level of T cell-dependent autoimmune responses.
|
15310853 |
2004 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, we outline the methods used to identify Ncf1 as one single susceptibility gene in a complex puzzle of inherited factors that render susceptibility to a complex autoimmune disorder like arthritis.
|
12869136 |
2003 |