|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negatively regulating miR-219-1.
|
31478245 |
2019 |
|
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1.This article is protected by copyright.All rights reserved.
|
29231252 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1.This article is protected by copyright.All rights reserved.
|
29231252 |
2017 |
|
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1.This article is protected by copyright.All rights reserved.
|
29231252 |
2017 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here we show that ∼95% of cervical tumor samples examined overexpress Cat-1, suggesting that the up-regulation of Cat-1 expression is a frequent occurrence in this type of cancer.
|
22807447 |
2012 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines.
|
21308737 |
2011 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines.
|
21308737 |
2011 |
|
Fetal Growth Retardation
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Normal or IUGR HUVEC monolayers were exposed (0-24h) to 5% O(2) (normoxia), and 1 or 2% O(2) (hypoxia). l-Arginine transport and hCAT-1 expression, phosphorylated and total PKCalpha or eNOS protein and mRNA expression were quantified. eNOS involvement was tested using a siRNA against eNOS (eNOS-siRNA) adenovirus.
|
19501907 |
2009 |
|
Endothelial dysfunction
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
It is therefore possible that binding of miR-122 to the 3'UTR may cause the depression of gene expression, contributing to the lesser level of SLC7A1 and the endothelial dysfunction seen in hypertensive subjects.
|
19067360 |
2009 |
|
Endothelial dysfunction
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.
|
17325243 |
2007 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies.
|
12480925 |
2002 |
|
Fetal Growth Retardation
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In summary, endothelium from fetuses with IUGR exhibit altered L-arginine transport and NO synthesis (L-arginine/NO pathway), reduced expression and activity of hCAT-1 and hCAT-2B and reduced eNOS activity.
|
12142345 |
2002 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results demonstrate that estrogen-inducible genes such as pS2 can be ERR targets and suggest that pharmacological modulation of ERRalpha activity may have therapeutic value in the treatment of breast cancer.
|
11559547 |
2001 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results demonstrate that estrogen-inducible genes such as pS2 can be ERR targets and suggest that pharmacological modulation of ERRalpha activity may have therapeutic value in the treatment of breast cancer.
|
11559547 |
2001 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection.
|
31648581 |
2019 |
|
BLV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings provide insights for BLV infection and for developing new strategies for treating BLV and preventing its spread.-Bai, L., Sato, H., Kubo, Y., Wada, S., Aida, Y. CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection.
|
31648581 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
STAT3 Targets <i>ERR-α</i> to Promote Epithelial-Mesenchymal Transition, Migration, and Invasion in Triple-Negative Breast Cancer Cells.
|
31427441 |
2019 |
|
Malignant neoplasm of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34).
|
29355960 |
2018 |
|
Bronchitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two definitions of CB using CAT 1/2 scores and SGRQ questions were used to phenotype CB among the study patients.
|
29942122 |
2018 |
|
Coughing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present study defined CB using CAT 1 and 2 scores and the questions on the severity of cough and sputum from the SGRQ.
|
29942122 |
2018 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34).
|
29355960 |
2018 |
|
Bicuspid aortic valve
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BAV TAA samples showed an increased concentration of putrescine and spermidine vs. TAV and donor samples, together with a decreased mRNA level of polyamine anabolic enzymes and of the putative polyamine transporter SLC7A1/CAT-1.
|
29147966 |
2018 |
|
Thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for attained age, sex, birth year, body mass index and pack-years smoked, we found no association between thyroid dose and thyroid cancer risk (ERR/100 mGy = -0.05, 95% CI <-0.10, 0.34).
|
29355960 |
2018 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show in large in silico patient cohorts that paediatric sarcomas and brain tumours express predominately the arginine transporter SLC7A1 and the arginine metabolising enzyme Arginase 2 (ARG2), but have low-absent expression of OTC.
|
28969007 |
2017 |
|
Muscle Rigidity
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Previous reports indicated that L<sup>300</sup>R mutation (LRR mutant) in E<sup>354</sup>R/Arg<sup>356</sup> double mutant (ERR mutant) from Lampyris turkestanicus luciferase has increased its thermal stability and rigidity through induction of some ionic bonds with Asp 270 and 271.
|
28322945 |
2017 |