Cardiovascular Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Endothelial dysfunction
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
It is therefore possible that binding of miR-122 to the 3'UTR may cause the depression of gene expression, contributing to the lesser level of SLC7A1 and the endothelial dysfunction seen in hypertensive subjects.
|
19067360 |
2009 |
Gestational Diabetes
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Insulin also reversed the GDM-associated increase in hCAT-1 protein abundance and mRNA expression, and SLC7A1 promoter activity for the fragment -606 bp from the transcription start point.
|
26710791 |
2016 |
Essential Hypertension
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In vivo and in vitro measures of L-arginine transport were substantially reduced in the essential hypertension and positive family history groups compared with the negative family history group; however, no difference was detected in peripheral blood mononuclear cell mRNA or protein expression levels for the cationic amino acid transporter CAT-1.
|
15569830 |
2004 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis.
|
28977838 |
2017 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis.
|
28977838 |
2017 |
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
In the present study, we characterized the distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry.
|
18172665 |
2008 |
Fetal Growth Retardation
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In summary, endothelium from fetuses with IUGR exhibit altered L-arginine transport and NO synthesis (L-arginine/NO pathway), reduced expression and activity of hCAT-1 and hCAT-2B and reduced eNOS activity.
|
12142345 |
2002 |
Malignant neoplasm of prostate
|
0.330 |
Biomarker
|
disease |
BEFREE |
In order to assess the role of CaT1 in generating endogenous store-operated Ca(2+) current (I(SOC)) in the lymph node carcinoma of the prostate (LNCaP) human prostate cancer epithelial cell line, we manipulated its endogenous levels by means of antisense hybrid depletion or pharmacological up-regulation (antiandrogen treatment) combined with functional evaluation of I(SOC).
|
12584203 |
2003 |
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In order to assess the role of CaT1 in generating endogenous store-operated Ca(2+) current (I(SOC)) in the lymph node carcinoma of the prostate (LNCaP) human prostate cancer epithelial cell line, we manipulated its endogenous levels by means of antisense hybrid depletion or pharmacological up-regulation (antiandrogen treatment) combined with functional evaluation of I(SOC).
|
12584203 |
2003 |
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negatively regulating miR-219-1.
|
31478245 |
2019 |
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negatively regulating miR-219-1.
|
31478245 |
2019 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negatively regulating miR-219-1.
|
31478245 |
2019 |
Malignant neoplasm of stomach
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1.This article is protected by copyright.All rights reserved.
|
29231252 |
2017 |
Stomach Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1.This article is protected by copyright.All rights reserved.
|
29231252 |
2017 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, these results suggested that CAT1 promotes the tumorigenesis and progression of GC by negative-regulating miR-219-1.This article is protected by copyright.All rights reserved.
|
29231252 |
2017 |
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In association with these biochemical indices, we observed a 38% reduction (P<0.05) in the mRNA expression of the cationic amino acid transporter CAT-1 in ventricular myocardial samples from patients with CHF compared with healthy unused donor myocardium, whereas myocardial NOS enzymatic activity and NOS protein were unchanged.
|
12480822 |
2002 |
Endothelial dysfunction
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.
|
17325243 |
2007 |
Hypertensive disease
|
0.040 |
Biomarker
|
group |
BEFREE |
Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.
|
17325243 |
2007 |
Hypertensive disease
|
0.040 |
GeneticVariation
|
group |
LHGDN |
Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.
|
17325243 |
2007 |
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here we show that ∼95% of cervical tumor samples examined overexpress Cat-1, suggesting that the up-regulation of Cat-1 expression is a frequent occurrence in this type of cancer.
|
22807447 |
2012 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show that ∼95% of cervical tumor samples examined overexpress Cat-1, suggesting that the up-regulation of Cat-1 expression is a frequent occurrence in this type of cancer.
|
22807447 |
2012 |
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here we show in large in silico patient cohorts that paediatric sarcomas and brain tumours express predominately the arginine transporter SLC7A1 and the arginine metabolising enzyme Arginase 2 (ARG2), but have low-absent expression of OTC.
|
28969007 |
2017 |
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
|
27841878 |
2017 |