Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
With one possible exception, none of these lymphoma VH sequences appear to represent any of the VH3 genes that may be preferentially used in the fetal repertoire.
|
1909196 |
1991 |
Lymphoma, Follicular
|
0.020 |
Biomarker
|
disease |
BEFREE |
The frequency of VH family use in FL was found to be similar to that reported for normal peripheral blood lymphocytes and is therefore also roughly proportional to VH family size.
|
1909196 |
1991 |
Lymphoma, Follicular
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Ig heavy chain variable region (VH) genes expressed by human diffuse large-cell lymphoma (DLC) and follicular lymphoma (FL) were identified and analyzed with respect to germline gene families.
|
7579401 |
1995 |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
To characterise the nature of the cellular origin of the blastic variant of mantle cell lymphoma (MCL-BV), we analysed the immunoglobulin (Ig) heavy chain variable region (V(H)) genes in four cases of MCL-BV.
|
10634642 |
2000 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Furthermore, this technological advance should be equally effective at identifying specific VH gene-expressing cells in other lymphoid malignancies, as well as in nonmalignant B cell disorders.
|
7883997 |
1995 |
Mantle cell lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To characterise the nature of the cellular origin of the blastic variant of mantle cell lymphoma (MCL-BV), we analysed the immunoglobulin (Ig) heavy chain variable region (V(H)) genes in four cases of MCL-BV.
|
10634642 |
2000 |
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The observed patterns of V(H) usage and mutations suggested that specific antigens may play a pathologically relevant role in the genesis or progression of thymic MALT lymphoma.
|
16353132 |
2006 |
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Based on the CDR3 sequence amplified from each MALT lymphoma, individual tumor-specific primers were synthesized and used directly in the polymerase chain reaction (PCR) to analyze the sequences of their Ig heavy-chain variable region.
|
7579460 |
1995 |
Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To characterize multiple myeloma (MM) from the viewpoint of the immunoglobulin (Ig) gene structure, we compared the transcripts of the Ig heavy chain variable region from 23 MM samples with 221 clones of the gamma, alpha and mu chain transcripts amplified by the reverse transcriptase-polymerase chain reaction (RT-PCR) from normal bone marrow (BM) cells.
|
8892685 |
1996 |
Multiple Myeloma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The immunoglobulin (Ig) heavy chain variable region (VH) gene sequence expressed by the malignant clone in MM can be used as a tumor specific marker.
|
7475288 |
1995 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Differential usage of an Ig heavy chain variable region gene by human B-cell tumors.
|
8324224 |
1993 |
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Although most of the VH genes expressed by DLC tumor cells contained mutations with respect to their germline counterparts, almost all of these mutations occurred before the clonal expansion of the tumor.
|
7579401 |
1995 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The immunoglobulin (Ig) heavy chain variable region (VH) gene sequence expressed by the malignant clone in MM can be used as a tumor specific marker.
|
7475288 |
1995 |
Rheumatoid Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We used restriction endonuclease generated polymorphism with human VH gene-family-specific probes to examine genomic DNA from a RA family and from unrelated RA patients from both the Tunisian and the European populations.
|
9189012 |
1997 |
Richter's syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To reveal whether Richter's syndrome occurs in CLLs with mutated or unmutated VH genes, we have performed mutational analysis on serial specimens from eight patients.
|
14671632 |
2004 |
Shprintzen syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
By chromosomal in situ hybridization and YAC identification, SLC7A4 was mapped to 22q11.2, the commonly deleted region of the velocardiofacial syndrome (VCFS, Shprintzen syndrome).
|
9598310 |
1998 |
Shprintzen-Goldberg syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
By chromosomal in situ hybridization and YAC identification, SLC7A4 was mapped to 22q11.2, the commonly deleted region of the velocardiofacial syndrome (VCFS, Shprintzen syndrome).
|
9598310 |
1998 |
Splenic Marginal Zone B-Cell Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes.
|
7888678 |
1995 |
Teratocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of SLC7A4 can be induced in NT2 teratocarcinoma cells by treatment with retinoic acid.
|
12049641 |
2002 |