SLC9A3, solute carrier family 9 member A3, 6550

N. diseases: 73; N. variants: 15
Disease: Chronic kidney disease stage 5 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5 		0.020 Biomarker disease BEFREE The selective sodium hydrogen exchanger 3 (NHE3) inhibitor tenapanor is being developed by Ardelyx Inc. for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) [under the tradename IBSRELA<sup>®</sup>] and for hyperphosphataemia in patients with chronic kidney disease (CKD) on dialysis or with end stage renal disease (ESRD). 31677150 2019
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5 		0.020 GeneticVariation disease BEFREE The NHE1 to NHE3 and NHE5 loci did not demonstrate evidence for linkage to ESRD. 10642288 2000