Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
A stratified analysis by ethnicity revealed that the NRAMP1 3'UTR polymorphism was associated with an increased risk of PTB in the Asian population, but not in Caucasian, African, and South American populations.The present results indicate that the NRAMP1 3'UTR polymorphism may be considered a risk factor for PTB in the Asian population.
|
31169721 |
2019 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between NRAMP1 polymorphisms and PTB risk.
|
28648687 |
2017 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NRAMP1 and VDR gene polymorphisms in susceptibility to pulmonary tuberculosis among Andhra Pradesh population in India: a case-control study.
|
28583097 |
2017 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population.
|
26774366 |
2016 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate natural-resistance-associated macrophage protein 1 (NRAMP1), mannose-binding lectin (MBL), vitamin D receptor (VDR) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis (PTB) in a Chinese population.
|
26261060 |
2015 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that polymorphisms in the SLC11A1 gene contribute to TB (both PTB and EPTB), particularly in Asians.
|
22326178 |
2012 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study, the first to include evidence on 577G/A and INT4, reports a significant association between SLC11A1 gene variants and PTB with respect to susceptibility and subsequent disease progression in East India.
|
22008758 |
2011 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NRAMP1 polymorphisms (3'UTR, D543N, INT4) were evaluated among 142 patients with culture-positive pulmonary tuberculosis and 144 ethnically matched healthy controls having latent M. tuberculosis infection.
|
21169917 |
2011 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variants in SLC11A1 increase susceptibility to pulmonary TB and interact with other variants that differ by race.
|
19723394 |
2009 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to determine the association of NRAMP1, VDR, and TNF-á variant with development of pulmonary tuberculosis (PTB) among Iranian patients.
|
20231985 |
2009 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined this hypothesis in Indonesia by spoligotyping M. tuberculosis isolates recovered from 336 patients with pulmonary tuberculosis and typing the patients' SLC11A1 gene (formerly known as "NRAMP1"), which is involved in susceptibility to tuberculosis.
|
19863441 |
2009 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggested that genetic variations in SLC11A1 may affect the incidence of MDR-TB and clinical features of pulmonary tuberculosis.
|
17950034 |
2008 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These data suggested that genetic variations in SLC11A1 may affect the incidence of MDR-TB and clinical features of pulmonary tuberculosis.
|
17950034 |
2008 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association between pulmonary tuberculosis and a microsatellite marker in the 5'(CA)n locus in the SLC11A1 gene compared with controls (38% versus 30% odds ratio 1.45, 95% CI: 1.06-1.9, P=0.014) was observed.
|
17157384 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to investigate the roles of AMs response-related genes TNF-alpha, iNOS, and NRAMP1 (SLC11A1) in susceptibility to silicosis and pulmonary tuberculosis (PTB), and to analyze the interaction of dust exposure and genetic susceptibility to silicosis, interactions of TNF-alpha-308 and Natural Resistance-associated Macrophage Protein 1 (NRAMP1) INT4, D543N polymorphisms to PTB.
|
17223386 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The aim of this study is to investigate the roles of AMs response-related genes TNF-alpha, iNOS, and NRAMP1 (SLC11A1) in susceptibility to silicosis and pulmonary tuberculosis (PTB), and to analyze the interaction of dust exposure and genetic susceptibility to silicosis, interactions of TNF-alpha-308 and Natural Resistance-associated Macrophage Protein 1 (NRAMP1) INT4, D543N polymorphisms to PTB.
|
17223386 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore the potential role of these genes in the susceptibility to pulmonary tuberculosis in a Mexican mestizo population, we evaluated the association of D543N and 3'-UTR polymorphisms in NRAMP1/SLC11 A1 and - 762 and A1513C polymorphisms in P2X(7) genes with the risk for tuberculosis.
|
17493019 |
2007 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Global distribution of a novel trinucleotide microsatellite polymorphism (ATA)n in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis.
|
16426236 |
2006 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The findings of the present study support the hypothesis that genetic variants of NRAMP1 may have an effect on bacilli growth and on outcomes of pulmonary tuberculosis, but not on susceptibility to M. tuberculosis infection.
|
15825023 |
2005 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The findings of the present study support the hypothesis that genetic variants of NRAMP1 may have an effect on bacilli growth and on outcomes of pulmonary tuberculosis, but not on susceptibility to M. tuberculosis infection.
|
15825023 |
2005 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygotes for the TGTG deletion (1729+55del4) in the 3'UTR of SLC11A1 were over-represented among PTB patients (P = 0.013; OR 5.19; 95% CI 1.42-18.94).
|
15636493 |
2004 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population.
|
15141734 |
2004 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the VDR and NRAMP1 gene are statistically associated with susceptibility to PTB in the Chinese Han population.
|
15141734 |
2004 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of D543N and 3'UTR locus in NRAMP1 gene might affect their susceptibility to TB in Chinese Han population.
|
14703493 |
2003 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the most convincing results were observed for HLA-DR2 and NRAMP1 (or a closely linked gene) in pulmonary tuberculosis and leprosy subtypes and for a 10p13 locus in paucibacillary leprosy, the molecular basis of their effects remains to be established.
|
14610288 |
2003 |