|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sirolimus plus nintedanib prevented vascular pathology in the oral mucosa, lungs, and liver of the BMP9/10ib mice, as well as significantly reduced gastrointestinal bleeding and anemia in inducible ALK1-deficient adult mice.
|
31689244 |
2020 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation.
|
31843555 |
2020 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation.
|
31843555 |
2020 |
|
Hepatolenticular Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum biochemical diagnostic ratios predicting WD-ALF (ALP: bilirubin and AST:ALT) were determined in these patients.
|
31838773 |
2020 |
|
Kidney Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, EOMABRSL induced hepatorenal damage by increasing the markers of liver toxicity (ALT, AST, ALP, GGT and bilirubin) and kidney failure (creatinine, urea, uric acid, and renal electrolytes-Na<sup>+</sup> and K<sup>+</sup>).
|
31760208 |
2020 |
|
Pleural Effusion, Malignant
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of our study was to analyze the prognostic value of the combination of serum ALP and pleural effusion LDH (AL score) for malignant pleural effusion (MPE) patients.
|
31837116 |
2020 |
|
Periosteal Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It was also tested that whether the acellular periosteum possess favorable osteogenesis induction activity attributed to ALP assay and quantitative real-time PCR (Col I, Runx2, OCN) assay.
|
31747647 |
2020 |
|
Liver Failure, Acute
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Serum biochemical diagnostic ratios predicting WD-ALF (ALP: bilirubin and AST:ALT) were determined in these patients.
|
31838773 |
2020 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Androgen receptor suppresses prostate cancer metastasis but promotes bladder cancer metastasis via differentially altering miRNA525-5p/SLPI-mediated vasculogenic mimicry formation.
|
31843555 |
2020 |
|
Liver regeneration disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Liver injury markers, such as albumin and SGOT, SGPT, and ALP activities, in serum indicated that ATO supplementation during liver regeneration hampers the rejuvenation process.
|
31270803 |
2020 |
|
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of our study was to analyze the prognostic value of the combination of serum ALP and pleural effusion LDH (AL score) for malignant pleural effusion (MPE) patients.
|
31837116 |
2020 |
|
Refractory anemias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RA significantly reduced the levels of ALP, MDA, Ca, and P but increased SOD levels.
|
30864863 |
2019 |
|
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, qRT-PCR demonstrated a significant upregulation of ALK1 mRNA expression in TAA tissues.
|
31623405 |
2019 |
|
Cholestasis, Extrahepatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alkaline phosphatase (ALP) is a significant biomarker in clinical diagnostics, and the abnormal level of ALP enzyme in serum is closely related to various diseases such as bone or liver cancer, bone metastases, and extrahepatic biliary obstruction.
|
31117415 |
2019 |
|
Bloom Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We used BS (4 mmol/L) inducing differentiation of LoVo cell and found after BS treated over 48h MS4A12 variant-1 (one of MS4A12 gene transcripts) as well as ALP and E-cadherin of LoVo cells were all increased significantly.
|
27881006 |
2019 |
|
Bone Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the production of ROS and the levels of PPAR<i>γ</i>, P53, and TNF<i>α</i> were much lower in group D than in group C. Additionally, the levels of ALP and extent of cell proliferation were much higher in group D than in group C. The results demonstrated the potential of AMI in reducing the side effects of radiation in BMSCs and in treatment of bone diseases caused by radiation.
|
30728842 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
DHI could significantly decrease the serum contents of IL-1β, TNF-α, IL-6, IL-8, IgM, IgG, IgA, MPO, hs-CRP, MDA, LDH, CK-MB, PAF, ALP and Cr, while elevate NO, SOD, TP and UA levels, indicating that DHI could inhibit inflammation and platelet aggregation, thereby relieving immune response and peroxidation, protecting vascular endothelial and organ function, and then prevent and treat cardiovascular diseases.
|
31302425 |
2019 |
|
Constipation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
ALP-2 treated groups could improve small intestinal movement rate and increase the weight of feces significantly in constipation mice.
|
30981336 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was a modest negative association of genetically predicted ALP with T2D risk and no evidence of association between GGT and T2D risk.
|
31088856 |
2019 |
|
Goiter
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, dietary RSM inclusion levels induced liver enlargement in ducklings at day 21 (5 to 20% double-low RSM with 1.37 to 5.31 µmol/g GLS) and thyroid enlargement accompanied by increased serum AST and ALP activities in ducks at day 42 (5 to 15% Indian RSM with 7.67 to 23.66 µmol/g GLS).
|
31347686 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: AAV: adeno-associated virus; AD: Alzheimer disease; ALP: autophagy-lysosomal pathway; ALS: amyotrophic lateral sclerosis; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; FTD: frontotemporal dementias; HD: Huntington disease; HTT: huntingtin; LIR: LC3-interacting region; NBR1: autophagy cargo receptor; NFE2L2/Nrf2: nuclear factor, erythroid derived 2, like 2; NFTs: neurofibrillary tangles; MAPT: microtubule associated protein tau; OPTN: optineurin; p-MAPT: hyperphosphorylated MAPT; PFA: paraformaldehyde; TARDBP/TDP-43: TAR DNA binding protein; TAX1BP1 Tax1: binding protein 1; ThioS: thioflavin-S; UBA: ubiquitin-associated.
|
30290707 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pneumonia was associated with higher SLPI than a non-pulmonary source of infection.
|
31089838 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
On day 1-2, subjects with sepsis had higher SLPI concentrations than those with non-septic BSI.
|
31089838 |
2019 |
|
Bacterial Vaginosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HIV+ postmenopausal compared to premenopausal participants had lower median E. coli bactericidal activity (41% vs. 62%, p = 0.001), lower median gene copies of Lactobacillus crispatus (p = 0.005) and Lactobacillus iners (p = 0.019), lower proportions of Lactobacillus iners, higher proportions of Gardnerella and Atopobium vaginae and lower levels of human beta defensins (HBD-2, HBD-3) and secretory leukocyte protease inhibitor (SLPI), p<0.001.
|
31026271 |
2019 |
|
Desmoplastic fibroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a tissue microarray technique (TMA), cases of myofibroma (MF), of nodular fasciitis (NF), of desmoplastic fibroma (DF), and of myofibroblastic sarcoma (MS) from the Universidad Autónoma Metropolitana Xochimilco, and a Private Oral Pathology Service in Mexico City were stained with antibodies against alpha-smooth muscle actin (α-SMA), H-caldesmon, vimentin, desmin, β-catenin, CD34, anaplastic lymphoma protein kinase (ALK-1), and Ki-67.
|
30168888 |
2019 |