|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alkaline phosphatase (ALP) is a significant biomarker in clinical diagnostics, and the abnormal level of ALP enzyme in serum is closely related to various diseases such as bone or liver cancer, bone metastases, and extrahepatic biliary obstruction.
|
31117415 |
2019 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A rare case of pulmonary IMS with ALK-1 gene rearrangement and multiple brain metastases responded to three generations of ALK inhibitors.
|
29925295 |
2019 |
|
Neuromuscular inhibition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All venoms increased TOTAL-CK, MB-CK, and LDH levels (indicating muscle injury) and ALT, AST, GGT, and ALP levels (markers of liver damage) and were able to induce a neuromuscular blockade.
|
31508780 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
On day 1-2, subjects with sepsis had higher SLPI concentrations than those with non-septic BSI.
|
31089838 |
2019 |
|
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Immunohistochemical staining demonstrated cells labeled with VIM (+), CD68PGM1 (+), CD34 (-), Actin (-), PCK (-), EMA (-), Desmin (-), SMA (-), S-100 (-), P63 (-), ALK-1 (-), beta-catenia (+), and KI67 (+).
|
31169683 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alkaline phosphatase (ALP) is a significant biomarker in clinical diagnostics, and the abnormal level of ALP enzyme in serum is closely related to various diseases such as bone or liver cancer, bone metastases, and extrahepatic biliary obstruction.
|
31117415 |
2019 |
|
Squamous cell carcinoma of vulva
|
0.010 |
Biomarker
|
disease |
BEFREE |
The data presented here indicate that SLPI plays a pivotal role in HPV-infection not only in HNSCC but also in VSCC and possibly also in other HPV-driven cancers.
|
30267960 |
2019 |
|
Deformity
|
0.010 |
Biomarker
|
group |
BEFREE |
After microinjection of miR-181a-5p mimic and inhibitor, zebrafish malformation type and percentage were prominently increased such as distorted SIV vessels along with reduced venation and abnormal branches by ALP staining.
|
30784759 |
2019 |
|
Vitelliform Macular Dystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, Prolactin could increase serum 1,25(OH)2D3 and ALP levels and decrease tibia BMD significantly without any change in PTH level.
|
30599794 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Alkaline phosphatase (ALP) is a significant biomarker in clinical diagnostics, and the abnormal level of ALP enzyme in serum is closely related to various diseases such as bone or liver cancer, bone metastases, and extrahepatic biliary obstruction.
|
31117415 |
2019 |
|
Muscle damage
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In comparison to control worms, it was observed that at high concentrations of ZnO NPs, most of the treated worms showed an increase in the levels of ALT, AST and ALP (worm muscle damage, and gonad injury); enhancement of the total protein content (worm cellular dysfunction); significant increase in MDA level (free radical-mediated worm cell membrane damage); depletion in GST and GSH activities (reduced ability to clear toxic compounds like lipid peroxides); CAT depletion (superoxide dismutase and hydrogen peroxide toxicity) and NO increase (detoxification activity and stressful conditions on worms).
|
31478140 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, targeting the PTK2-TBK1-SQSTM1 axis may represent a novel therapeutic intervention for neurodegenerative diseases with TARDBP proteinopathies.<b>Abbreviations</b>: ALP: macroautophagy/autophagy lysosomal pathway; ALS: amyotrophic lateral sclerosis; ATXN2: ataxin 2; BafA1: bafilomycin A<sub>1</sub>; cCASP3: cleaved caspase 3; CSNK2: casein kinase 2; FTLD: frontotemporal lobar degeneration; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; OPTN: optineurin; PTK2/FAK: PTK2 protein tyrosine kinase 2; SQSTM1/p62: sequestosome 1; TARDBP/TDP-43: TAR DNA binding protein; TBK1: TANK binding kinase 1; ULK1: unc-51 like autophagy activating kinase 1; UPS: ubiquitin-proteasome system.
|
31690171 |
2019 |
|
Becker Muscular Dystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, Prolactin could increase serum 1,25(OH)2D3 and ALP levels and decrease tibia BMD significantly without any change in PTH level.
|
30599794 |
2019 |
|
Myofibroma (morphologic abnormality)
|
0.010 |
Biomarker
|
disease |
BEFREE |
1/2 of the MS cases were positive for desmin; 6/10 of the DF cases were positive for β-catenin, and 2 of the MF cases were positive for ALK-1.
|
30168888 |
2019 |
|
Solitary Myofibromatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
1/2 of the MS cases were positive for desmin; 6/10 of the DF cases were positive for β-catenin, and 2 of the MF cases were positive for ALK-1.
|
30168888 |
2019 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, ALT, AST, ALP, γ-GT, TBIL, and other indexes were positively correlated to the Th17/Treg ratio (P <.05).Th17/Treg cell level and its ratio in peripheral blood of patients with SS complicated with primary biliary cirrhosis were significantly unbalanced, indicating that Th17 cells participate in the onset of this disease to a large extent.
|
31192933 |
2019 |
|
Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Analysis of data is accompanied with the significant histopathological changes (steatosis, ballooning and inflammation), increased lipid profile and hepatic enzyme activities (AST, ALT, ALP) plus TBARS as well as decreased antioxidants levels in NASH model.
|
31010354 |
2019 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate whether SLPI production differs depending on etiology, disease severity, and sex in BSI and to correlate SLPI with markers of inflammation and immunosuppression.
|
31089838 |
2019 |
|
Immunoglobulin G4-Related Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time RT-PCR showed that the levels of mRNAs encoding TCNI and SLPI, except for BPI and LTF, were significantly lower in patients with IgG4-RD than in healthy people.
|
31116057 |
2019 |
|
Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Analysis of data is accompanied with the significant histopathological changes (steatosis, ballooning and inflammation), increased lipid profile and hepatic enzyme activities (AST, ALT, ALP) plus TBARS as well as decreased antioxidants levels in NASH model.
|
31010354 |
2019 |
|
Acromegaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
OC and bone ALP were negatively associated with RANKL in the acromegaly group (r=-0.384, p=0.036 and r=-0.528, p=0.003, respectively).
|
29895074 |
2018 |
|
Bone neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The area under the curve value for sB7-H3 (0.868) was markedly higher than those for ALP (0.713) and CA125 (0.789) for differentiating between OS patients and other begin bone tumor patients.
|
30123093 |
2018 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The vascular specific BMP (bone morphogenetic protein) receptor ALK1 (activin-like kinase receptor type I) and its circulating ligand BMP9 have been shown to be potent vascular quiescence factors, but their role in the context of microvascular permeability associated with hyperglycemia has not been evaluated.
|
29880487 |
2018 |
|
Leukoplakia, Oral
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the correlation between the abundance of SLPI protein and the different histological grades of OL by immunohistochemistry.
|
29436667 |
2018 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients without cirrhosis showed a significant decline of ALP and bilirubin levels after the first two interventions.
|
30125307 |
2018 |