|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we show that SMARCB1 loss causes increased BRD9 incorporation into SWI/SNF thus providing insight into BRD9 vulnerability in RTs.
|
31015438 |
2019 |
|
Rhabdoid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We show that loss of SMARCB1, a subunit of the SWI/SNF (BAF) complex mutated in nearly all MRTs, sensitized cells to MDM2 and MDM2/4 inhibition by enhancing p53-mediated apoptosis.
|
30755442 |
2019 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Abnormalities of SMARCB1 (INI1), which encodes a member of the SWI/SNF pathway, are found in neoplasms with rhabdoid morphology, such as malignant rhabdoid tumour of the kidney and atypical teratoid/rhabdoid tumour of the central nervous system.
|
27656868 |
2017 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
SMARCB1 (also known as SNF5, INI1, and BAF47), a core subunit of the SWI/SNF (BAF) chromatin-remodeling complex, is inactivated in nearly all pediatric rhabdoid tumors.
|
27941797 |
2017 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alterations in this gene, or the related SWI/SNF chromatin remodeling gene SMARCB1, have been previously reported in atypical teratoid/rhabdoid tumors (ATRTs) and malignant rhabdoid tumors (MRTs).
|
26646792 |
2016 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data establish that SNF5 loss during MRT development alters the repertoire of available SWI/SNF complexes, generally disrupting those associated with cellular differentiation.
|
25009291 |
2014 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The silencing of the SWI/SNF subunit and anticancer gene BRM in Rhabdoid tumors.
|
24913006 |
2014 |
|
Rhabdoid Tumor
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show that SNF5 recruits the SWI/SNF complex to the BIN1 promoter, and that the marked reduction of BIN1 expression in RT correlates with decreased SWI/SNF occupancy.
|
22544318 |
2012 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
INI1/hSNF5 is a component of the chromatin remodeling SWI/SNF complex and a tumor suppressor deleted in RT.
|
21521802 |
2011 |
|
Rhabdoid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified inactivation of another member of the SWI/SNF chromatin-remodeling complex, its ATPase subunit SMARCA4 (also known as BRG1), due to a SMARCA4/BRG1 germline mutation and loss of heterozygosity by uniparental disomy in the tumor cells of two sisters with rhabdoid tumors lacking SMARCB1 mutations.
|
20137775 |
2010 |
|
Rhabdoid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Malignant rhabdoid tumor (MRT) is a rare and aggressive tumor associated with deletion or mutation of a tumor suppressor gene SMARCB1/INI1, a member of the SWI/SNF chromatin-remodeling complex.
|
17040295 |
2006 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Ini1 subunit of the SWI/SNF chromatin remodeling complex suppresses formation of malignant rhabdoid tumors in humans and mice.
|
16912184 |
2006 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SMARCB1/INI1 gene encodes for an invariant subunit of SWI/SNF chromatin remodeling complex and has been previously reported to act as a tumor suppressor gene frequently inactivated in infantile malignant rhabdoid tumors.
|
15899790 |
2005 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hSNF5 subunit of human SWI/SNF ATP-dependent chromatin remodeling complexes is a tumor suppressor that is inactivated in malignant rhabdoid tumors (MRTs).
|
15769941 |
2005 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
hSNF5, the smallest member of the SWI/SNF chromatin remodeling complex, is lost in most malignant rhabdoid tumors (MRT).
|
16288006 |
2005 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
Truncating mutations and homozygous deletions in the hSNF5/INI1/BAF47 subunit of human SWI/SNF complexes occur in most malignant rhabdoid tumors and some other malignancies.
|
12149641 |
2002 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors.
|
11782395 |
2002 |
|
Rhabdoid Tumor
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hSNF5/INI1 gene, which encodes a subunit of the SWI/SNF family of chromatin-remodeling complexes and is located at 22q11.2, has been reported as a tumor suppressor gene inactivated in malignant rhabdoid tumors (MRTs).
|
11921280 |
2002 |
|
Rhabdoid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This deleted region is close to hSNF5/INI1 (SMARCB1), a gene that encodes a widely expressed component of the SWI/SNF chromatin remodeling complex and that suffers biallelic mutations in malignant rhabdoid tumors.
|
10463572 |
1999 |
|
Rhabdoid Tumor
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The hSNF5/INI1 gene which encodes a member of the SWI/SNF chromatin ATP-dependent remodeling complex, is a new tumor suppressor gene localized on chromosome 22q11.2 and recently shown to be mutated in malignant rhabdoid tumors.
|
10556283 |
1999 |