SMPD1, sphingomyelin phosphodiesterase 1, 6609

N. diseases: 247; N. variants: 130
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.020 Biomarker disease BEFREE Finally, inhibition of ASM by amitriptyline improved drug sensitivity in MM cell lines and primary MM cells. 31756922 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.020 Biomarker disease BEFREE We found that aSMase activity in the blood of patients with MM (at the time of diagnosis) was 305.43 pmol/spot*20 h, and this value was significantly lower (<i>p</i> < 0.030) compared to the healthy group 441.88 pmol/spot*20 h. Our collected data suggest a possible role of aSMase in pathogenesis of MM development. 31801274 2019