SMPD1, sphingomyelin phosphodiesterase 1, 6609

N. diseases: 247; N. variants: 130
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.050 Biomarker disease BEFREE A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. 31835809 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.050 Biomarker disease BEFREE Several drugs that are commonly used to treat MDD functionally inhibit the lysosomal enzyme ASM and are called functional inhibitors of ASM (FIASMAs). 30191367 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.050 Biomarker disease BEFREE Many antidepressants are functional inhibitors of the acid sphingomyelinase and were designed for systemic treatment of major depression. 29698625 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.050 AlteredExpression disease BEFREE Thus, we asked whether chronic psychosocial stress as a detrimental factor contributing to the emergence of MDD would also affect ASM activity and sphingolipid (SL) metabolism. 30386262 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.050 Biomarker disease BEFREE This study shows that the ASM alternative splicing pattern could be a biological target with diagnostic relevance and could serve as a novel biomarker for MDD. 27866044 2017